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Optimized SNR-based ECAP threshold determination is comparable to the judgement of human evaluators

In cochlear implant (CI) users, measurements of electrically evoked compound action potentials (ECAPs) prove the functionality of the neuron-electrode interface. Objective measures, e.g., the ECAP threshold, may serve as a basis for the clinical adjustment of the device for the optimal benefit of th...

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Autores principales: Gärtner, Lutz, Spitzer, Philipp, Lauss, Kathrin, Takanen, Marko, Lenarz, Thomas, Hoth, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559956/
https://www.ncbi.nlm.nih.gov/pubmed/34723991
http://dx.doi.org/10.1371/journal.pone.0259347
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author Gärtner, Lutz
Spitzer, Philipp
Lauss, Kathrin
Takanen, Marko
Lenarz, Thomas
Hoth, Sebastian
author_facet Gärtner, Lutz
Spitzer, Philipp
Lauss, Kathrin
Takanen, Marko
Lenarz, Thomas
Hoth, Sebastian
author_sort Gärtner, Lutz
collection PubMed
description In cochlear implant (CI) users, measurements of electrically evoked compound action potentials (ECAPs) prove the functionality of the neuron-electrode interface. Objective measures, e.g., the ECAP threshold, may serve as a basis for the clinical adjustment of the device for the optimal benefit of the CI user. As for many neural responses, the threshold determination often is based on the subjective assessment of the clinical specialist, whose decision-making process could be aided by autonomous computational algorithms. To that end, we extended the signal-to-noise ratio (SNR) approach for ECAP threshold determination to be applicable for FineGrain (FG) ECAP responses. The new approach takes advantage of two features: the FG stimulation paradigm with its enhanced resolution of recordings, and SNR-based ECAP threshold determination, which allows defining thresholds independently of morphology and with comparably low computational power. Pearson’s correlation coefficient r between the ECAP threshold determined by five experienced evaluators and the threshold determined with the FG-SNR algorithm was in the range of r = 0.78–0.93. Between evaluators, r was in a comparable range of 0.84–0.93. A subset of the parameters of the algorithm was varied to identify the parameters with the highest potential to improve the FG-SNR formalism in the future. The two steps with the strongest influence on the agreement between the threshold estimate of the evaluators and the algorithm were the removal of undesired frequency components (denoising of the response traces) and the exact determination of the two time windows (signal and noise and noise only).”The parameters were linked to the properties of an ECAP response, indicating how to adjust the algorithm for the automatic detection of other neurophysiological responses.
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spelling pubmed-85599562021-11-02 Optimized SNR-based ECAP threshold determination is comparable to the judgement of human evaluators Gärtner, Lutz Spitzer, Philipp Lauss, Kathrin Takanen, Marko Lenarz, Thomas Hoth, Sebastian PLoS One Research Article In cochlear implant (CI) users, measurements of electrically evoked compound action potentials (ECAPs) prove the functionality of the neuron-electrode interface. Objective measures, e.g., the ECAP threshold, may serve as a basis for the clinical adjustment of the device for the optimal benefit of the CI user. As for many neural responses, the threshold determination often is based on the subjective assessment of the clinical specialist, whose decision-making process could be aided by autonomous computational algorithms. To that end, we extended the signal-to-noise ratio (SNR) approach for ECAP threshold determination to be applicable for FineGrain (FG) ECAP responses. The new approach takes advantage of two features: the FG stimulation paradigm with its enhanced resolution of recordings, and SNR-based ECAP threshold determination, which allows defining thresholds independently of morphology and with comparably low computational power. Pearson’s correlation coefficient r between the ECAP threshold determined by five experienced evaluators and the threshold determined with the FG-SNR algorithm was in the range of r = 0.78–0.93. Between evaluators, r was in a comparable range of 0.84–0.93. A subset of the parameters of the algorithm was varied to identify the parameters with the highest potential to improve the FG-SNR formalism in the future. The two steps with the strongest influence on the agreement between the threshold estimate of the evaluators and the algorithm were the removal of undesired frequency components (denoising of the response traces) and the exact determination of the two time windows (signal and noise and noise only).”The parameters were linked to the properties of an ECAP response, indicating how to adjust the algorithm for the automatic detection of other neurophysiological responses. Public Library of Science 2021-11-01 /pmc/articles/PMC8559956/ /pubmed/34723991 http://dx.doi.org/10.1371/journal.pone.0259347 Text en © 2021 Gärtner et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gärtner, Lutz
Spitzer, Philipp
Lauss, Kathrin
Takanen, Marko
Lenarz, Thomas
Hoth, Sebastian
Optimized SNR-based ECAP threshold determination is comparable to the judgement of human evaluators
title Optimized SNR-based ECAP threshold determination is comparable to the judgement of human evaluators
title_full Optimized SNR-based ECAP threshold determination is comparable to the judgement of human evaluators
title_fullStr Optimized SNR-based ECAP threshold determination is comparable to the judgement of human evaluators
title_full_unstemmed Optimized SNR-based ECAP threshold determination is comparable to the judgement of human evaluators
title_short Optimized SNR-based ECAP threshold determination is comparable to the judgement of human evaluators
title_sort optimized snr-based ecap threshold determination is comparable to the judgement of human evaluators
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559956/
https://www.ncbi.nlm.nih.gov/pubmed/34723991
http://dx.doi.org/10.1371/journal.pone.0259347
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