No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants

The association between proton pump inhibitors' (PPIs) use and mortality remains unclear. METHODS: This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression. RESULTS: After adjusting for confounders, such as over he...

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Autores principales: He, Qiangsheng, Xia, Bin, Meng, Wenbo, Fan, Die, Kuo, Zi-Chong, Huang, Junjie, Qin, Xiwen, Zou, Huachun, He, Yulong, Zhang, Changhua, Fang, Shuo, Pan, Yihang, Yang, Man, Yuan, Jinqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560155/
https://www.ncbi.nlm.nih.gov/pubmed/34313608
http://dx.doi.org/10.14309/ajg.0000000000001377
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author He, Qiangsheng
Xia, Bin
Meng, Wenbo
Fan, Die
Kuo, Zi-Chong
Huang, Junjie
Qin, Xiwen
Zou, Huachun
He, Yulong
Zhang, Changhua
Fang, Shuo
Pan, Yihang
Yang, Man
Yuan, Jinqiu
author_facet He, Qiangsheng
Xia, Bin
Meng, Wenbo
Fan, Die
Kuo, Zi-Chong
Huang, Junjie
Qin, Xiwen
Zou, Huachun
He, Yulong
Zhang, Changhua
Fang, Shuo
Pan, Yihang
Yang, Man
Yuan, Jinqiu
author_sort He, Qiangsheng
collection PubMed
description The association between proton pump inhibitors' (PPIs) use and mortality remains unclear. METHODS: This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression. RESULTS: After adjusting for confounders, such as over health status and longstanding diseases, the regular use of PPIs was not associated with an increased risk of all-cause mortality and mortality due to neoplasms, circulatory system diseases, respiratory system diseases, digestive system diseases, external causes, and other causes. DISCUSSION: Regular use of PPIs was not associated with an increased risk of all-cause and cause-specific mortality.
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spelling pubmed-85601552021-11-05 No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants He, Qiangsheng Xia, Bin Meng, Wenbo Fan, Die Kuo, Zi-Chong Huang, Junjie Qin, Xiwen Zou, Huachun He, Yulong Zhang, Changhua Fang, Shuo Pan, Yihang Yang, Man Yuan, Jinqiu Am J Gastroenterol Brief Communication The association between proton pump inhibitors' (PPIs) use and mortality remains unclear. METHODS: This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression. RESULTS: After adjusting for confounders, such as over health status and longstanding diseases, the regular use of PPIs was not associated with an increased risk of all-cause mortality and mortality due to neoplasms, circulatory system diseases, respiratory system diseases, digestive system diseases, external causes, and other causes. DISCUSSION: Regular use of PPIs was not associated with an increased risk of all-cause and cause-specific mortality. Wolters Kluwer 2021-11 2021-07-27 /pmc/articles/PMC8560155/ /pubmed/34313608 http://dx.doi.org/10.14309/ajg.0000000000001377 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Brief Communication
He, Qiangsheng
Xia, Bin
Meng, Wenbo
Fan, Die
Kuo, Zi-Chong
Huang, Junjie
Qin, Xiwen
Zou, Huachun
He, Yulong
Zhang, Changhua
Fang, Shuo
Pan, Yihang
Yang, Man
Yuan, Jinqiu
No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants
title No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants
title_full No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants
title_fullStr No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants
title_full_unstemmed No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants
title_short No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants
title_sort no associations between regular use of proton pump inhibitors and risk of all-cause and cause-specific mortality: a population-based cohort of 0.44 million participants
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560155/
https://www.ncbi.nlm.nih.gov/pubmed/34313608
http://dx.doi.org/10.14309/ajg.0000000000001377
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