lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p

Ovarian cancer is a kind of cancer from the female genital tract; the molecular mechanism still needs to be explored. lncRNA plays a vital role in tumorigenesis and development. Our aim was to identify oncogenic lncRNAs in ovarian cancer and explore the potential molecular mechanism. SNHG15 was init...

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Autores principales: Wang, Yi, Ding, Minghong, Yuan, Xiaoqing, Jiao, Ruibao, Zhu, Dagao, Huang, Wanzhong, Deng, Wenxia, Liu, Yulong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560251/
https://www.ncbi.nlm.nih.gov/pubmed/34734088
http://dx.doi.org/10.1155/2021/9394563
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author Wang, Yi
Ding, Minghong
Yuan, Xiaoqing
Jiao, Ruibao
Zhu, Dagao
Huang, Wanzhong
Deng, Wenxia
Liu, Yulong
author_facet Wang, Yi
Ding, Minghong
Yuan, Xiaoqing
Jiao, Ruibao
Zhu, Dagao
Huang, Wanzhong
Deng, Wenxia
Liu, Yulong
author_sort Wang, Yi
collection PubMed
description Ovarian cancer is a kind of cancer from the female genital tract; the molecular mechanism still needs to be explored. lncRNA plays a vital role in tumorigenesis and development. Our aim was to identify oncogenic lncRNAs in ovarian cancer and explore the potential molecular mechanism. SNHG15 was initially identified by using GEO datasets (GSE135886 and GSE119054) and validated by tumor tissues and the cell line, identifying that SNHG15 was upregulated in ovarian cancer. Besides, high SNHG15 indicated poor prognosis in ovarian cancer. Furthermore, knockdown SNHG15 suppresses ovarian cancer proliferation and promotes apoptosis. Mechanistically, SNHG15 promotes proliferation through upregulated CDK6 via sponging miR-370-3p. Taken together, our findings emphasize the important role of SNHG15 in ovarian cancer, suggesting that SNHG15 may be a promising target for ovarian cancer.
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spelling pubmed-85602512021-11-02 lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p Wang, Yi Ding, Minghong Yuan, Xiaoqing Jiao, Ruibao Zhu, Dagao Huang, Wanzhong Deng, Wenxia Liu, Yulong Biomed Res Int Research Article Ovarian cancer is a kind of cancer from the female genital tract; the molecular mechanism still needs to be explored. lncRNA plays a vital role in tumorigenesis and development. Our aim was to identify oncogenic lncRNAs in ovarian cancer and explore the potential molecular mechanism. SNHG15 was initially identified by using GEO datasets (GSE135886 and GSE119054) and validated by tumor tissues and the cell line, identifying that SNHG15 was upregulated in ovarian cancer. Besides, high SNHG15 indicated poor prognosis in ovarian cancer. Furthermore, knockdown SNHG15 suppresses ovarian cancer proliferation and promotes apoptosis. Mechanistically, SNHG15 promotes proliferation through upregulated CDK6 via sponging miR-370-3p. Taken together, our findings emphasize the important role of SNHG15 in ovarian cancer, suggesting that SNHG15 may be a promising target for ovarian cancer. Hindawi 2021-10-25 /pmc/articles/PMC8560251/ /pubmed/34734088 http://dx.doi.org/10.1155/2021/9394563 Text en Copyright © 2021 Yi Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Yi
Ding, Minghong
Yuan, Xiaoqing
Jiao, Ruibao
Zhu, Dagao
Huang, Wanzhong
Deng, Wenxia
Liu, Yulong
lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p
title lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p
title_full lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p
title_fullStr lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p
title_full_unstemmed lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p
title_short lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p
title_sort lncrna snhg15 promotes ovarian cancer progression through regulated cdk6 via sponging mir-370-3p
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560251/
https://www.ncbi.nlm.nih.gov/pubmed/34734088
http://dx.doi.org/10.1155/2021/9394563
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