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Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression

Background. Dengue virus (DENV) infection is the most common arboviral disease that affects tropical and subtropical regions. Based on the clinical hallmarks, the different severities of patients range from mild dengue fever (MDF) to severe dengue diseases (SDDs) and include dengue hemorrhagic fever...

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Autores principales: Nanda, Josephine Diony, Jung, Chiau-Jing, Satria, Rahmat Dani, Jhan, Ming-Kai, Shen, Ting-Jing, Tseng, Po-Chun, Wang, Yung-Ting, Ho, Tzong-Shiann, Lin, Chiou-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560270/
https://www.ncbi.nlm.nih.gov/pubmed/34734091
http://dx.doi.org/10.1155/2021/7652569
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author Nanda, Josephine Diony
Jung, Chiau-Jing
Satria, Rahmat Dani
Jhan, Ming-Kai
Shen, Ting-Jing
Tseng, Po-Chun
Wang, Yung-Ting
Ho, Tzong-Shiann
Lin, Chiou-Feng
author_facet Nanda, Josephine Diony
Jung, Chiau-Jing
Satria, Rahmat Dani
Jhan, Ming-Kai
Shen, Ting-Jing
Tseng, Po-Chun
Wang, Yung-Ting
Ho, Tzong-Shiann
Lin, Chiou-Feng
author_sort Nanda, Josephine Diony
collection PubMed
description Background. Dengue virus (DENV) infection is the most common arboviral disease that affects tropical and subtropical regions. Based on the clinical hallmarks, the different severities of patients range from mild dengue fever (MDF) to severe dengue diseases (SDDs) and include dengue hemorrhagic fever or dengue shock syndrome. These are commonly associated with cytokine release syndrome (CRS). The types and levels of cytokines/chemokines, which are suppressed or enhanced, are varied, indicating CRS's pathogenic and host defensive effects. Principal Finding. In this study, we created an integrated and precise multiplex panel of cytokine/chemokine assays based on our literature analysis to monitor dengue CRS. A 24-plex panel of cytokines/chemokines was evaluated to measure the plasma levels of targeting factors in dengue patients with an MDF and SDD diagnosis without or with comorbidities. As identified in sixteen kinds of cytokines/chemokines, ten were significantly (P < 0.05) (10/16) increased, one was significantly (P < 0.01) (1/16) decreased, and five were potentially (5/16) altered in all dengue patients (n = 30) in the acute phase of disease onset. Compared to MDF, the levels of IL-8 (CXCL-8) and IL-18 in SDD were markedly (P < 0.05) increased, accompanied by positively increased IL-6 and TNF-α and decreased IFN-γ and RANTES. With comorbidities, SDD significantly (P < 0.01) portrayed elevated IL-18 accompanied by increased IL-6 and decreased IFN-α2 and IL-12. In addition, decreased platelets were significantly (P < 0.05) associated with increased IL-18. Significance. These results demonstrate an efficient panel of dengue cytokine/chemokine assays used to explore the possible level of CRS during the acute phase of disease onset; also, we are the first to report the increase of IL-18 in severe dengue with comorbidity compared to severe dengue without comorbidity and mild dengue.
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spelling pubmed-85602702021-11-02 Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression Nanda, Josephine Diony Jung, Chiau-Jing Satria, Rahmat Dani Jhan, Ming-Kai Shen, Ting-Jing Tseng, Po-Chun Wang, Yung-Ting Ho, Tzong-Shiann Lin, Chiou-Feng J Immunol Res Research Article Background. Dengue virus (DENV) infection is the most common arboviral disease that affects tropical and subtropical regions. Based on the clinical hallmarks, the different severities of patients range from mild dengue fever (MDF) to severe dengue diseases (SDDs) and include dengue hemorrhagic fever or dengue shock syndrome. These are commonly associated with cytokine release syndrome (CRS). The types and levels of cytokines/chemokines, which are suppressed or enhanced, are varied, indicating CRS's pathogenic and host defensive effects. Principal Finding. In this study, we created an integrated and precise multiplex panel of cytokine/chemokine assays based on our literature analysis to monitor dengue CRS. A 24-plex panel of cytokines/chemokines was evaluated to measure the plasma levels of targeting factors in dengue patients with an MDF and SDD diagnosis without or with comorbidities. As identified in sixteen kinds of cytokines/chemokines, ten were significantly (P < 0.05) (10/16) increased, one was significantly (P < 0.01) (1/16) decreased, and five were potentially (5/16) altered in all dengue patients (n = 30) in the acute phase of disease onset. Compared to MDF, the levels of IL-8 (CXCL-8) and IL-18 in SDD were markedly (P < 0.05) increased, accompanied by positively increased IL-6 and TNF-α and decreased IFN-γ and RANTES. With comorbidities, SDD significantly (P < 0.01) portrayed elevated IL-18 accompanied by increased IL-6 and decreased IFN-α2 and IL-12. In addition, decreased platelets were significantly (P < 0.05) associated with increased IL-18. Significance. These results demonstrate an efficient panel of dengue cytokine/chemokine assays used to explore the possible level of CRS during the acute phase of disease onset; also, we are the first to report the increase of IL-18 in severe dengue with comorbidity compared to severe dengue without comorbidity and mild dengue. Hindawi 2021-10-25 /pmc/articles/PMC8560270/ /pubmed/34734091 http://dx.doi.org/10.1155/2021/7652569 Text en Copyright © 2021 Josephine Diony Nanda et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nanda, Josephine Diony
Jung, Chiau-Jing
Satria, Rahmat Dani
Jhan, Ming-Kai
Shen, Ting-Jing
Tseng, Po-Chun
Wang, Yung-Ting
Ho, Tzong-Shiann
Lin, Chiou-Feng
Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
title Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
title_full Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
title_fullStr Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
title_full_unstemmed Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
title_short Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
title_sort serum il-18 is a potential biomarker for predicting severe dengue disease progression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560270/
https://www.ncbi.nlm.nih.gov/pubmed/34734091
http://dx.doi.org/10.1155/2021/7652569
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