Expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab

INTRODUCTION: Tertiary lymphoid structure expression and immune checkpoint inhibitors have been attracting attention, and their relationship with renal cell carcinoma is controversial. CASE PRESENTATION: Two patients with nivolumab plus ipilimumab treatment response for metastatic renal cell carcino...

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Autores principales: Sazuka, Tomokazu, Fujimoto, Ayumi, Sato, Hiroaki, Arai, Takayuki, Imamura, Yusuke, Sakamoto, Shinichi, Ikeda, Jun‐ichiro, Ichikawa, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560443/
https://www.ncbi.nlm.nih.gov/pubmed/34755054
http://dx.doi.org/10.1002/iju5.12347
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author Sazuka, Tomokazu
Fujimoto, Ayumi
Sato, Hiroaki
Arai, Takayuki
Imamura, Yusuke
Sakamoto, Shinichi
Ikeda, Jun‐ichiro
Ichikawa, Tomohiko
author_facet Sazuka, Tomokazu
Fujimoto, Ayumi
Sato, Hiroaki
Arai, Takayuki
Imamura, Yusuke
Sakamoto, Shinichi
Ikeda, Jun‐ichiro
Ichikawa, Tomohiko
author_sort Sazuka, Tomokazu
collection PubMed
description INTRODUCTION: Tertiary lymphoid structure expression and immune checkpoint inhibitors have been attracting attention, and their relationship with renal cell carcinoma is controversial. CASE PRESENTATION: Two patients with nivolumab plus ipilimumab treatment response for metastatic renal cell carcinoma underwent cytoreductive nephrectomy and regional lymph node dissection. In both cases, the renal tumor site expressed tertiary lymphoid structures. Despite the absence of treatment after a deferred cytoreductive nephrectomy and the short postoperative observation period, the patients still survived. CONCLUSION: Tertiary lymphoid structures were expressed in deferred cytoreductive nephrectomy specimen in cases treated with nivolumab plus ipilimumab.
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spelling pubmed-85604432021-11-08 Expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab Sazuka, Tomokazu Fujimoto, Ayumi Sato, Hiroaki Arai, Takayuki Imamura, Yusuke Sakamoto, Shinichi Ikeda, Jun‐ichiro Ichikawa, Tomohiko IJU Case Rep Case Reports INTRODUCTION: Tertiary lymphoid structure expression and immune checkpoint inhibitors have been attracting attention, and their relationship with renal cell carcinoma is controversial. CASE PRESENTATION: Two patients with nivolumab plus ipilimumab treatment response for metastatic renal cell carcinoma underwent cytoreductive nephrectomy and regional lymph node dissection. In both cases, the renal tumor site expressed tertiary lymphoid structures. Despite the absence of treatment after a deferred cytoreductive nephrectomy and the short postoperative observation period, the patients still survived. CONCLUSION: Tertiary lymphoid structures were expressed in deferred cytoreductive nephrectomy specimen in cases treated with nivolumab plus ipilimumab. John Wiley and Sons Inc. 2021-08-16 /pmc/articles/PMC8560443/ /pubmed/34755054 http://dx.doi.org/10.1002/iju5.12347 Text en © 2021 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Sazuka, Tomokazu
Fujimoto, Ayumi
Sato, Hiroaki
Arai, Takayuki
Imamura, Yusuke
Sakamoto, Shinichi
Ikeda, Jun‐ichiro
Ichikawa, Tomohiko
Expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab
title Expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab
title_full Expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab
title_fullStr Expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab
title_full_unstemmed Expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab
title_short Expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab
title_sort expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560443/
https://www.ncbi.nlm.nih.gov/pubmed/34755054
http://dx.doi.org/10.1002/iju5.12347
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