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Laparoscopic resection of aortocaval paraganglioma diagnosed by serial increase in urinary metanephrines after bilateral adrenalectomy in a patient with multiple endocrine neoplasia type 2A
INTRODUCTION: Although bilateral pheochromocytoma is prevalent in patients with multiple endocrine neoplasia type 2, extra‐adrenal tumors rarely occur in the aortocaval area. CASE PRESENTATION: A 35‐year‐old man with multiple endocrine neoplasia type 2A (RET codon Cys634Arg mutation) underwent bilat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560458/ https://www.ncbi.nlm.nih.gov/pubmed/34755052 http://dx.doi.org/10.1002/iju5.12345 |
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author | Miyata, Yushi Hatano, Koji Okuno, Yosuke Ujike, Takeshi Fukuhara, Shinichiro Uemura, Motohide Kiuchi, Hiroshi Imamura, Ryoichi Otsuki, Michio Nonomura, Norio |
author_facet | Miyata, Yushi Hatano, Koji Okuno, Yosuke Ujike, Takeshi Fukuhara, Shinichiro Uemura, Motohide Kiuchi, Hiroshi Imamura, Ryoichi Otsuki, Michio Nonomura, Norio |
author_sort | Miyata, Yushi |
collection | PubMed |
description | INTRODUCTION: Although bilateral pheochromocytoma is prevalent in patients with multiple endocrine neoplasia type 2, extra‐adrenal tumors rarely occur in the aortocaval area. CASE PRESENTATION: A 35‐year‐old man with multiple endocrine neoplasia type 2A (RET codon Cys634Arg mutation) underwent bilateral adrenalectomy for metachronous pheochromocytoma. After bilateral adrenalectomy, urinary metanephrines decreased below the measurement sensitivity. The levels of urinary metanephrines were serially elevating to a peak of 187 ng/mgCr during the 11‐year follow‐up period; however, urinary normetanephrine levels remained almost stable. (123)I‐metaiodobenzylguanidine single‐photon emission computed tomography revealed abnormal accumulation with a mass of 25 × 18 mm in diameter in the aortocaval space cranially to the renal vessels. The extra‐adrenal paraganglioma was successfully resected using transperitoneal laparoscopic surgery. CONCLUSION: The serial increase in urinary metanephrine levels was useful for the detection of the recurrent tumor in a patient who had undergone bilateral adrenalectomy. |
format | Online Article Text |
id | pubmed-8560458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85604582021-11-08 Laparoscopic resection of aortocaval paraganglioma diagnosed by serial increase in urinary metanephrines after bilateral adrenalectomy in a patient with multiple endocrine neoplasia type 2A Miyata, Yushi Hatano, Koji Okuno, Yosuke Ujike, Takeshi Fukuhara, Shinichiro Uemura, Motohide Kiuchi, Hiroshi Imamura, Ryoichi Otsuki, Michio Nonomura, Norio IJU Case Rep Case Reports INTRODUCTION: Although bilateral pheochromocytoma is prevalent in patients with multiple endocrine neoplasia type 2, extra‐adrenal tumors rarely occur in the aortocaval area. CASE PRESENTATION: A 35‐year‐old man with multiple endocrine neoplasia type 2A (RET codon Cys634Arg mutation) underwent bilateral adrenalectomy for metachronous pheochromocytoma. After bilateral adrenalectomy, urinary metanephrines decreased below the measurement sensitivity. The levels of urinary metanephrines were serially elevating to a peak of 187 ng/mgCr during the 11‐year follow‐up period; however, urinary normetanephrine levels remained almost stable. (123)I‐metaiodobenzylguanidine single‐photon emission computed tomography revealed abnormal accumulation with a mass of 25 × 18 mm in diameter in the aortocaval space cranially to the renal vessels. The extra‐adrenal paraganglioma was successfully resected using transperitoneal laparoscopic surgery. CONCLUSION: The serial increase in urinary metanephrine levels was useful for the detection of the recurrent tumor in a patient who had undergone bilateral adrenalectomy. John Wiley and Sons Inc. 2021-07-04 /pmc/articles/PMC8560458/ /pubmed/34755052 http://dx.doi.org/10.1002/iju5.12345 Text en © 2021 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Miyata, Yushi Hatano, Koji Okuno, Yosuke Ujike, Takeshi Fukuhara, Shinichiro Uemura, Motohide Kiuchi, Hiroshi Imamura, Ryoichi Otsuki, Michio Nonomura, Norio Laparoscopic resection of aortocaval paraganglioma diagnosed by serial increase in urinary metanephrines after bilateral adrenalectomy in a patient with multiple endocrine neoplasia type 2A |
title | Laparoscopic resection of aortocaval paraganglioma diagnosed by serial increase in urinary metanephrines after bilateral adrenalectomy in a patient with multiple endocrine neoplasia type 2A |
title_full | Laparoscopic resection of aortocaval paraganglioma diagnosed by serial increase in urinary metanephrines after bilateral adrenalectomy in a patient with multiple endocrine neoplasia type 2A |
title_fullStr | Laparoscopic resection of aortocaval paraganglioma diagnosed by serial increase in urinary metanephrines after bilateral adrenalectomy in a patient with multiple endocrine neoplasia type 2A |
title_full_unstemmed | Laparoscopic resection of aortocaval paraganglioma diagnosed by serial increase in urinary metanephrines after bilateral adrenalectomy in a patient with multiple endocrine neoplasia type 2A |
title_short | Laparoscopic resection of aortocaval paraganglioma diagnosed by serial increase in urinary metanephrines after bilateral adrenalectomy in a patient with multiple endocrine neoplasia type 2A |
title_sort | laparoscopic resection of aortocaval paraganglioma diagnosed by serial increase in urinary metanephrines after bilateral adrenalectomy in a patient with multiple endocrine neoplasia type 2a |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560458/ https://www.ncbi.nlm.nih.gov/pubmed/34755052 http://dx.doi.org/10.1002/iju5.12345 |
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