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Morc2a p.S87L mutant mice develop peripheral and central neuropathies associated with neuronal DNA damage and apoptosis

The microrchidia (MORC)-family CW-type zinc finger 2 (MORC2) gene is related to DNA repair, adipogenesis and epigenetic silencing via the human silencing hub (HUSH) complex. MORC2 missense mutation is known to cause peripheral neuropathy of Charcot-Marie-Tooth disease type 2 Z (CMT2Z). However, ther...

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Detalles Bibliográficos
Autores principales:	Lee, Geon Seong, Kwak, Geon, Bae, Ji Hyun, Han, Jeong Pil, Nam, Soo Hyun, Lee, Jeong Hyeon, Song, Sumin, Kim, Gap-Don, Park, Tae Sub, Choi, Yang Kyu, Choi, Byung-Ok, Yeom, Su Cheong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560500/ https://www.ncbi.nlm.nih.gov/pubmed/34695197 http://dx.doi.org/10.1242/dmm.049123

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