Cargando…

Pyroptosis: A promising therapeutic target for noninfectious diseases

Pyroptosis, which is characterized by gasdermin family protein‐mediated pore formation, cellular lysis and the release of pro‐inflammatory cytokines, is a form of programmed cell death associated with intracellular pathogens‐induced infection. However, emerging evidence indicates that pyroptosis als...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Tong, Zheng, Guangjuan, Li, Ben, Tang, Lipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560609/
https://www.ncbi.nlm.nih.gov/pubmed/34590363
http://dx.doi.org/10.1111/cpr.13137
_version_ 1784592952850382848
author Li, Tong
Zheng, Guangjuan
Li, Ben
Tang, Lipeng
author_facet Li, Tong
Zheng, Guangjuan
Li, Ben
Tang, Lipeng
author_sort Li, Tong
collection PubMed
description Pyroptosis, which is characterized by gasdermin family protein‐mediated pore formation, cellular lysis and the release of pro‐inflammatory cytokines, is a form of programmed cell death associated with intracellular pathogens‐induced infection. However, emerging evidence indicates that pyroptosis also contributes to sterile inflammation. In this review, we will first illustrate the biological process of pyroptosis. Then, we will focus on the pathogenic effects of pyroptosis on multiple noninfectious disorders. At last, we will characterize several specific pyroptotic inhibitors targeting the pyroptotic signalling pathway. These data demonstrate that pyroptosis plays a prominent role in sterile diseases, thereby providing a promising approach to the treatment of noninfective inflammatory disorders.
format Online
Article
Text
id pubmed-8560609
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-85606092021-11-08 Pyroptosis: A promising therapeutic target for noninfectious diseases Li, Tong Zheng, Guangjuan Li, Ben Tang, Lipeng Cell Prolif Reviews Pyroptosis, which is characterized by gasdermin family protein‐mediated pore formation, cellular lysis and the release of pro‐inflammatory cytokines, is a form of programmed cell death associated with intracellular pathogens‐induced infection. However, emerging evidence indicates that pyroptosis also contributes to sterile inflammation. In this review, we will first illustrate the biological process of pyroptosis. Then, we will focus on the pathogenic effects of pyroptosis on multiple noninfectious disorders. At last, we will characterize several specific pyroptotic inhibitors targeting the pyroptotic signalling pathway. These data demonstrate that pyroptosis plays a prominent role in sterile diseases, thereby providing a promising approach to the treatment of noninfective inflammatory disorders. John Wiley and Sons Inc. 2021-09-29 /pmc/articles/PMC8560609/ /pubmed/34590363 http://dx.doi.org/10.1111/cpr.13137 Text en © 2021 The Authors. Cell Proliferation published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Li, Tong
Zheng, Guangjuan
Li, Ben
Tang, Lipeng
Pyroptosis: A promising therapeutic target for noninfectious diseases
title Pyroptosis: A promising therapeutic target for noninfectious diseases
title_full Pyroptosis: A promising therapeutic target for noninfectious diseases
title_fullStr Pyroptosis: A promising therapeutic target for noninfectious diseases
title_full_unstemmed Pyroptosis: A promising therapeutic target for noninfectious diseases
title_short Pyroptosis: A promising therapeutic target for noninfectious diseases
title_sort pyroptosis: a promising therapeutic target for noninfectious diseases
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560609/
https://www.ncbi.nlm.nih.gov/pubmed/34590363
http://dx.doi.org/10.1111/cpr.13137
work_keys_str_mv AT litong pyroptosisapromisingtherapeutictargetfornoninfectiousdiseases
AT zhengguangjuan pyroptosisapromisingtherapeutictargetfornoninfectiousdiseases
AT liben pyroptosisapromisingtherapeutictargetfornoninfectiousdiseases
AT tanglipeng pyroptosisapromisingtherapeutictargetfornoninfectiousdiseases