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Pyroptosis: A promising therapeutic target for noninfectious diseases
Pyroptosis, which is characterized by gasdermin family protein‐mediated pore formation, cellular lysis and the release of pro‐inflammatory cytokines, is a form of programmed cell death associated with intracellular pathogens‐induced infection. However, emerging evidence indicates that pyroptosis als...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560609/ https://www.ncbi.nlm.nih.gov/pubmed/34590363 http://dx.doi.org/10.1111/cpr.13137 |
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author | Li, Tong Zheng, Guangjuan Li, Ben Tang, Lipeng |
author_facet | Li, Tong Zheng, Guangjuan Li, Ben Tang, Lipeng |
author_sort | Li, Tong |
collection | PubMed |
description | Pyroptosis, which is characterized by gasdermin family protein‐mediated pore formation, cellular lysis and the release of pro‐inflammatory cytokines, is a form of programmed cell death associated with intracellular pathogens‐induced infection. However, emerging evidence indicates that pyroptosis also contributes to sterile inflammation. In this review, we will first illustrate the biological process of pyroptosis. Then, we will focus on the pathogenic effects of pyroptosis on multiple noninfectious disorders. At last, we will characterize several specific pyroptotic inhibitors targeting the pyroptotic signalling pathway. These data demonstrate that pyroptosis plays a prominent role in sterile diseases, thereby providing a promising approach to the treatment of noninfective inflammatory disorders. |
format | Online Article Text |
id | pubmed-8560609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85606092021-11-08 Pyroptosis: A promising therapeutic target for noninfectious diseases Li, Tong Zheng, Guangjuan Li, Ben Tang, Lipeng Cell Prolif Reviews Pyroptosis, which is characterized by gasdermin family protein‐mediated pore formation, cellular lysis and the release of pro‐inflammatory cytokines, is a form of programmed cell death associated with intracellular pathogens‐induced infection. However, emerging evidence indicates that pyroptosis also contributes to sterile inflammation. In this review, we will first illustrate the biological process of pyroptosis. Then, we will focus on the pathogenic effects of pyroptosis on multiple noninfectious disorders. At last, we will characterize several specific pyroptotic inhibitors targeting the pyroptotic signalling pathway. These data demonstrate that pyroptosis plays a prominent role in sterile diseases, thereby providing a promising approach to the treatment of noninfective inflammatory disorders. John Wiley and Sons Inc. 2021-09-29 /pmc/articles/PMC8560609/ /pubmed/34590363 http://dx.doi.org/10.1111/cpr.13137 Text en © 2021 The Authors. Cell Proliferation published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Li, Tong Zheng, Guangjuan Li, Ben Tang, Lipeng Pyroptosis: A promising therapeutic target for noninfectious diseases |
title | Pyroptosis: A promising therapeutic target for noninfectious diseases |
title_full | Pyroptosis: A promising therapeutic target for noninfectious diseases |
title_fullStr | Pyroptosis: A promising therapeutic target for noninfectious diseases |
title_full_unstemmed | Pyroptosis: A promising therapeutic target for noninfectious diseases |
title_short | Pyroptosis: A promising therapeutic target for noninfectious diseases |
title_sort | pyroptosis: a promising therapeutic target for noninfectious diseases |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560609/ https://www.ncbi.nlm.nih.gov/pubmed/34590363 http://dx.doi.org/10.1111/cpr.13137 |
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