Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system

Opioid overdose, dependence, and addiction are a major public health crisis. Patients with chronic kidney disease (CKD) are at high risk of opioid overdose, therefore novel methods that provide accurate prediction of renal clearance (CL(r)) and systemic disposition of opioids in CKD patients can fac...

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Detalles Bibliográficos
Autores principales: Imaoka, Tomoki, Huang, Weize, Shum, Sara, Hailey, Dale W., Chang, Shih-Yu, Chapron, Alenka, Yeung, Catherine K., Himmelfarb, Jonathan, Isoherranen, Nina, Kelly, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560754/
https://www.ncbi.nlm.nih.gov/pubmed/34725352
http://dx.doi.org/10.1038/s41598-021-00338-y

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