EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma

Both EZH2 and its homolog EZH1 function as histone H3 Lysine 27 (H3K27) methyltransferases and repress the transcription of target genes. Dysregulation of H3K27 trimethylation (H3K27me3) plays an important role in the development and progression of cancers such as hepatocellular carcinoma (HCC). Thi...

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Detalles Bibliográficos
Autores principales: Kusakabe, Yuko, Chiba, Tetsuhiro, Oshima, Motohiko, Koide, Shuhei, Rizq, Ola, Aoyama, Kazumasa, Ao, Junjie, Kaneko, Tatsuya, Kanzaki, Hiroaki, Kanayama, Kengo, Maeda, Takahiro, Saito, Tomoko, Nakagawa, Ryo, Kobayashi, Kazufumi, Kiyono, Soichiro, Nakamura, Masato, Ogasawara, Sadahisa, Suzuki, Eiichiro, Nakamoto, Shingo, Yasui, Shin, Mikata, Rintaro, Muroyama, Ryosuke, Kanda, Tatsuo, Maruyama, Hitoshi, Kato, Jun, Mimura, Naoya, Ma, Anqi, Jin, Jian, Zen, Yoh, Otsuka, Masayuki, Kaneda, Atsushi, Iwama, Atsushi, Kato, Naoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560765/
https://www.ncbi.nlm.nih.gov/pubmed/34725436
http://dx.doi.org/10.1038/s41598-021-00889-0

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