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CYP3A-status is associated with blood concentration and dose-requirement of tacrolimus in heart transplant recipients

High inter-individual variability in tacrolimus clearance is attributed to genetic polymorphisms of CYP3A enzymes. However, due to CYP3A phenoconversion induced by non-genetic factors, continuous changes in tacrolimus-metabolizing capacity entail frequent dose-refinement for optimal immunosuppressio...

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Detalles Bibliográficos
Autores principales:	Déri, Máté, Szakál-Tóth, Zsófia, Fekete, Ferenc, Mangó, Katalin, Incze, Evelyn, Minus, Annamária, Merkely, Béla, Sax, Balázs, Monostory, Katalin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560807/ https://www.ncbi.nlm.nih.gov/pubmed/34725418 http://dx.doi.org/10.1038/s41598-021-00942-y

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