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Biomimetic cellulose-based superabsorbent hydrogels for treating obesity

In the treatment of obesity, nutritional and behavioral modifications are difficult to implement and maintain. Since vegetable consumption is a fundamental part of many dietary interventions and daily nutrient requirements, we developed a novel cellulose-based superabsorbent hydrogel (CB-SAH) platfo...

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Autores principales: Madaghiele, Marta, Demitri, Christian, Surano, Ivo, Silvestri, Alessandra, Vitale, Milena, Panteca, Eliana, Zohar, Yishai, Rescigno, Maria, Sannino, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560814/
https://www.ncbi.nlm.nih.gov/pubmed/34725434
http://dx.doi.org/10.1038/s41598-021-00884-5
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author Madaghiele, Marta
Demitri, Christian
Surano, Ivo
Silvestri, Alessandra
Vitale, Milena
Panteca, Eliana
Zohar, Yishai
Rescigno, Maria
Sannino, Alessandro
author_facet Madaghiele, Marta
Demitri, Christian
Surano, Ivo
Silvestri, Alessandra
Vitale, Milena
Panteca, Eliana
Zohar, Yishai
Rescigno, Maria
Sannino, Alessandro
author_sort Madaghiele, Marta
collection PubMed
description In the treatment of obesity, nutritional and behavioral modifications are difficult to implement and maintain. Since vegetable consumption is a fundamental part of many dietary interventions and daily nutrient requirements, we developed a novel cellulose-based superabsorbent hydrogel (CB-SAH) platform, inspired by the composition and mechanical properties of raw vegetables, as a mechanobiological therapy. The CB-SAHs properties were studied in a simulated gastrointestinal environment, while their impact on gut tissue was investigated by an ex vivo organ culture (EVOC) model. Functional fibers and raw vegetables were used as reference. CB-SAHs demonstrated orders of magnitude higher elasticity in comparison to the tested functional fibers, however performed similar to the tested raw vegetables. Notably, the biomimetic CB-SAHs with elasticity levels similar to raw vegetables showed benefits in preserving and regulating the gut tissue in the EVOC model. Non-systemic oral mechanotherapeutics based on this technology were advanced through clinical studies, with a first product cleared as an aid for weight management in the US and Europe.
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spelling pubmed-85608142021-11-03 Biomimetic cellulose-based superabsorbent hydrogels for treating obesity Madaghiele, Marta Demitri, Christian Surano, Ivo Silvestri, Alessandra Vitale, Milena Panteca, Eliana Zohar, Yishai Rescigno, Maria Sannino, Alessandro Sci Rep Article In the treatment of obesity, nutritional and behavioral modifications are difficult to implement and maintain. Since vegetable consumption is a fundamental part of many dietary interventions and daily nutrient requirements, we developed a novel cellulose-based superabsorbent hydrogel (CB-SAH) platform, inspired by the composition and mechanical properties of raw vegetables, as a mechanobiological therapy. The CB-SAHs properties were studied in a simulated gastrointestinal environment, while their impact on gut tissue was investigated by an ex vivo organ culture (EVOC) model. Functional fibers and raw vegetables were used as reference. CB-SAHs demonstrated orders of magnitude higher elasticity in comparison to the tested functional fibers, however performed similar to the tested raw vegetables. Notably, the biomimetic CB-SAHs with elasticity levels similar to raw vegetables showed benefits in preserving and regulating the gut tissue in the EVOC model. Non-systemic oral mechanotherapeutics based on this technology were advanced through clinical studies, with a first product cleared as an aid for weight management in the US and Europe. Nature Publishing Group UK 2021-11-01 /pmc/articles/PMC8560814/ /pubmed/34725434 http://dx.doi.org/10.1038/s41598-021-00884-5 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Madaghiele, Marta
Demitri, Christian
Surano, Ivo
Silvestri, Alessandra
Vitale, Milena
Panteca, Eliana
Zohar, Yishai
Rescigno, Maria
Sannino, Alessandro
Biomimetic cellulose-based superabsorbent hydrogels for treating obesity
title Biomimetic cellulose-based superabsorbent hydrogels for treating obesity
title_full Biomimetic cellulose-based superabsorbent hydrogels for treating obesity
title_fullStr Biomimetic cellulose-based superabsorbent hydrogels for treating obesity
title_full_unstemmed Biomimetic cellulose-based superabsorbent hydrogels for treating obesity
title_short Biomimetic cellulose-based superabsorbent hydrogels for treating obesity
title_sort biomimetic cellulose-based superabsorbent hydrogels for treating obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560814/
https://www.ncbi.nlm.nih.gov/pubmed/34725434
http://dx.doi.org/10.1038/s41598-021-00884-5
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