Cargando…
Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
TRPV6 is a calcium-selective ion channel implicated in epithelial Ca(2+) uptake. TRPV6 inhibitors are needed for the treatment of a broad range of diseases associated with disturbed calcium homeostasis, including cancers. Here we combine cryo-EM, calcium imaging, and mutagenesis to explore molecular...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560856/ https://www.ncbi.nlm.nih.gov/pubmed/34725357 http://dx.doi.org/10.1038/s41467-021-26608-x |