Identification of the first highly selective inhibitor of human lactate dehydrogenase B

Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD(+); it has two isoforms, LDHA and LDHB. LDHA is a promising target for cancer therapy, whereas LDHB is necessary for basal autophagy and cancer cell proliferation in oxidative and glycolytic cancer cells. To...

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Detalles Bibliográficos
Autores principales: Shibata, Sachio, Sogabe, Satoshi, Miwa, Masanori, Fujimoto, Takuya, Takakura, Nobuyuki, Naotsuka, Akihiko, Kitamura, Shuji, Kawamoto, Tomohiro, Soga, Tomoyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560939/
https://www.ncbi.nlm.nih.gov/pubmed/34725423
http://dx.doi.org/10.1038/s41598-021-00820-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560939/
https://www.ncbi.nlm.nih.gov/pubmed/34725423
http://dx.doi.org/10.1038/s41598-021-00820-7

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