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Identification of the first highly selective inhibitor of human lactate dehydrogenase B
Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD(+); it has two isoforms, LDHA and LDHB. LDHA is a promising target for cancer therapy, whereas LDHB is necessary for basal autophagy and cancer cell proliferation in oxidative and glycolytic cancer cells. To...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560939/ https://www.ncbi.nlm.nih.gov/pubmed/34725423 http://dx.doi.org/10.1038/s41598-021-00820-7 |