The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains

The Linear Ubiquitin Chain Assembly Complex (LUBAC), composed of HOIP, HOIL-1L, and SHARPIN, promotes tumor necrosis factor (TNF)-dependent NF-κB signaling in diverse cell types. HOIL-1L contains an Npl4 Zinc Finger (NZF) domain that specifically recognizes linear ubiquitin chains, but its physiolog...

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Detalles Bibliográficos
Autores principales: Gomez-Diaz, Carlos, Jonsson, Gustav, Schodl, Katrin, Deszcz, Luiza, Bestehorn, Annika, Eislmayr, Kevin, Almagro, Jorge, Kavirayani, Anoop, Seida, Mayu, Fennell, Lilian M., Hagelkruys, Astrid, Kovarik, Pavel, Penninger, Josef M., Ikeda, Fumiyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561004/
https://www.ncbi.nlm.nih.gov/pubmed/34755089
http://dx.doi.org/10.1016/j.isci.2021.103241

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