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Neutrophils in pregnancy: New insights into innate and adaptive immune regulation

The immunology of pregnancy has been the focus of many studies to better understand how the mother is able to tolerate the presence of a semi‐allogeneic fetus. Far from the initial view of pregnancy as a state of immunosuppression, successful fetal development from implantation to birth is now known...

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Detalles Bibliográficos
Autores principales: Bert, Serena, Ward, Eleanor J., Nadkarni, Suchita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561097/
https://www.ncbi.nlm.nih.gov/pubmed/34287859
http://dx.doi.org/10.1111/imm.13392
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author Bert, Serena
Ward, Eleanor J.
Nadkarni, Suchita
author_facet Bert, Serena
Ward, Eleanor J.
Nadkarni, Suchita
author_sort Bert, Serena
collection PubMed
description The immunology of pregnancy has been the focus of many studies to better understand how the mother is able to tolerate the presence of a semi‐allogeneic fetus. Far from the initial view of pregnancy as a state of immunosuppression, successful fetal development from implantation to birth is now known to be under the control of an intricate balance of immune cells. The balance between pro‐inflammatory functions used to promote embryo implantation and placental development and immunosuppressive activity to maintain maternal tolerance of the fetus is an immunological phenotype unique to pregnancy, which is dependent on the time of gestation. Neutrophils are one of a host of innate immune cells detected at the maternal–fetal interface, but very little is known of their function. In this review, we explore the emerging functions of neutrophils during pregnancy and their interactions with and regulation of T cells, a key adaptive immune cell population essential for the establishment of fetal–maternal tolerance.
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spelling pubmed-85610972021-11-08 Neutrophils in pregnancy: New insights into innate and adaptive immune regulation Bert, Serena Ward, Eleanor J. Nadkarni, Suchita Immunology Neutrophil influence on adaptive immunity Series Editor: Emily Gwyer Findlay The immunology of pregnancy has been the focus of many studies to better understand how the mother is able to tolerate the presence of a semi‐allogeneic fetus. Far from the initial view of pregnancy as a state of immunosuppression, successful fetal development from implantation to birth is now known to be under the control of an intricate balance of immune cells. The balance between pro‐inflammatory functions used to promote embryo implantation and placental development and immunosuppressive activity to maintain maternal tolerance of the fetus is an immunological phenotype unique to pregnancy, which is dependent on the time of gestation. Neutrophils are one of a host of innate immune cells detected at the maternal–fetal interface, but very little is known of their function. In this review, we explore the emerging functions of neutrophils during pregnancy and their interactions with and regulation of T cells, a key adaptive immune cell population essential for the establishment of fetal–maternal tolerance. John Wiley and Sons Inc. 2021-07-29 2021-12 /pmc/articles/PMC8561097/ /pubmed/34287859 http://dx.doi.org/10.1111/imm.13392 Text en © 2021 The Authors. Immunology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Neutrophil influence on adaptive immunity Series Editor: Emily Gwyer Findlay
Bert, Serena
Ward, Eleanor J.
Nadkarni, Suchita
Neutrophils in pregnancy: New insights into innate and adaptive immune regulation
title Neutrophils in pregnancy: New insights into innate and adaptive immune regulation
title_full Neutrophils in pregnancy: New insights into innate and adaptive immune regulation
title_fullStr Neutrophils in pregnancy: New insights into innate and adaptive immune regulation
title_full_unstemmed Neutrophils in pregnancy: New insights into innate and adaptive immune regulation
title_short Neutrophils in pregnancy: New insights into innate and adaptive immune regulation
title_sort neutrophils in pregnancy: new insights into innate and adaptive immune regulation
topic Neutrophil influence on adaptive immunity Series Editor: Emily Gwyer Findlay
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561097/
https://www.ncbi.nlm.nih.gov/pubmed/34287859
http://dx.doi.org/10.1111/imm.13392
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