Pathogenicity of the MAGE family

The melanoma antigen gene (MAGE) protein family is a group of highly conserved proteins that share a common homology domain. Under normal circumstances, numerous MAGE proteins are only expressed in reproduction-related tissues; however, abnormal expression levels are observed in a variety of tumor t...

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Detalles Bibliográficos
Autores principales: Li, Sanyan, Shi, Xiang, Li, Jingping, Zhou, Xianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561213/
https://www.ncbi.nlm.nih.gov/pubmed/34733362
http://dx.doi.org/10.3892/ol.2021.13105
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author Li, Sanyan
Shi, Xiang
Li, Jingping
Zhou, Xianrong
author_facet Li, Sanyan
Shi, Xiang
Li, Jingping
Zhou, Xianrong
author_sort Li, Sanyan
collection PubMed
description The melanoma antigen gene (MAGE) protein family is a group of highly conserved proteins that share a common homology domain. Under normal circumstances, numerous MAGE proteins are only expressed in reproduction-related tissues; however, abnormal expression levels are observed in a variety of tumor tissues. The MAGE family consists of type I and II proteins, several of which are cancer-testis antigens that are highly expressed in cancer and serve a critical role in tumorigenesis. Therefore, this review will use the relationship between MAGEs and tumors as a starting point, focusing on the latest developments regarding the function of MAGEs as oncogenes, and preliminarily reveal their possible mechanisms.
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spelling pubmed-85612132021-11-02 Pathogenicity of the MAGE family Li, Sanyan Shi, Xiang Li, Jingping Zhou, Xianrong Oncol Lett Review The melanoma antigen gene (MAGE) protein family is a group of highly conserved proteins that share a common homology domain. Under normal circumstances, numerous MAGE proteins are only expressed in reproduction-related tissues; however, abnormal expression levels are observed in a variety of tumor tissues. The MAGE family consists of type I and II proteins, several of which are cancer-testis antigens that are highly expressed in cancer and serve a critical role in tumorigenesis. Therefore, this review will use the relationship between MAGEs and tumors as a starting point, focusing on the latest developments regarding the function of MAGEs as oncogenes, and preliminarily reveal their possible mechanisms. D.A. Spandidos 2021-12 2021-10-21 /pmc/articles/PMC8561213/ /pubmed/34733362 http://dx.doi.org/10.3892/ol.2021.13105 Text en Copyright: © Li et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Li, Sanyan
Shi, Xiang
Li, Jingping
Zhou, Xianrong
Pathogenicity of the MAGE family
title Pathogenicity of the MAGE family
title_full Pathogenicity of the MAGE family
title_fullStr Pathogenicity of the MAGE family
title_full_unstemmed Pathogenicity of the MAGE family
title_short Pathogenicity of the MAGE family
title_sort pathogenicity of the mage family
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561213/
https://www.ncbi.nlm.nih.gov/pubmed/34733362
http://dx.doi.org/10.3892/ol.2021.13105
work_keys_str_mv AT lisanyan pathogenicityofthemagefamily
AT shixiang pathogenicityofthemagefamily
AT lijingping pathogenicityofthemagefamily
AT zhouxianrong pathogenicityofthemagefamily

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