Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis

We investigated the value of susceptibility testing in predicting response in AIDS-associated cryptococcal meningitis using clinical isolates from a randomized controlled trial of antifungal treatment (amphotericin monotherapy, amphotericin with flucytosine, or amphotericin with fluconazole). We fou...

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Detalles Bibliográficos
Autores principales: O’Connor, Lucy, Van Anh, Duong, Chau, Tran Thi Hong, Chau, Nguyen Van Vinh, Huong, Lan Nguyen Phu, Wolbers, Marcel, Day, Jeremy N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Online Only Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561241/
https://www.ncbi.nlm.nih.gov/pubmed/33051650
http://dx.doi.org/10.1093/cid/ciaa1544
Descripción
Sumario:We investigated the value of susceptibility testing in predicting response in AIDS-associated cryptococcal meningitis using clinical isolates from a randomized controlled trial of antifungal treatment (amphotericin monotherapy, amphotericin with flucytosine, or amphotericin with fluconazole). We found no correlation between antifungal susceptibility and either early or late survival, or fungal clearance.

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