Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis

We investigated the value of susceptibility testing in predicting response in AIDS-associated cryptococcal meningitis using clinical isolates from a randomized controlled trial of antifungal treatment (amphotericin monotherapy, amphotericin with flucytosine, or amphotericin with fluconazole). We fou...

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Autores principales: O’Connor, Lucy, Van Anh, Duong, Chau, Tran Thi Hong, Chau, Nguyen Van Vinh, Huong, Lan Nguyen Phu, Wolbers, Marcel, Day, Jeremy N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Online Only Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561241/
https://www.ncbi.nlm.nih.gov/pubmed/33051650
http://dx.doi.org/10.1093/cid/ciaa1544
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author O’Connor, Lucy
Van Anh, Duong
Chau, Tran Thi Hong
Chau, Nguyen Van Vinh
Huong, Lan Nguyen Phu
Wolbers, Marcel
Day, Jeremy N
author_facet O’Connor, Lucy
Van Anh, Duong
Chau, Tran Thi Hong
Chau, Nguyen Van Vinh
Huong, Lan Nguyen Phu
Wolbers, Marcel
Day, Jeremy N
author_sort O’Connor, Lucy
collection PubMed
description We investigated the value of susceptibility testing in predicting response in AIDS-associated cryptococcal meningitis using clinical isolates from a randomized controlled trial of antifungal treatment (amphotericin monotherapy, amphotericin with flucytosine, or amphotericin with fluconazole). We found no correlation between antifungal susceptibility and either early or late survival, or fungal clearance.
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spelling pubmed-85612412021-11-03 Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis O’Connor, Lucy Van Anh, Duong Chau, Tran Thi Hong Chau, Nguyen Van Vinh Huong, Lan Nguyen Phu Wolbers, Marcel Day, Jeremy N Clin Infect Dis Online Only Articles We investigated the value of susceptibility testing in predicting response in AIDS-associated cryptococcal meningitis using clinical isolates from a randomized controlled trial of antifungal treatment (amphotericin monotherapy, amphotericin with flucytosine, or amphotericin with fluconazole). We found no correlation between antifungal susceptibility and either early or late survival, or fungal clearance. Oxford University Press 2020-10-14 /pmc/articles/PMC8561241/ /pubmed/33051650 http://dx.doi.org/10.1093/cid/ciaa1544 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Online Only Articles
O’Connor, Lucy
Van Anh, Duong
Chau, Tran Thi Hong
Chau, Nguyen Van Vinh
Huong, Lan Nguyen Phu
Wolbers, Marcel
Day, Jeremy N
Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis
title Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis
title_full Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis
title_fullStr Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis
title_full_unstemmed Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis
title_short Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis
title_sort antifungal susceptibility does not correlate with fungal clearance or survival in aids-associated cryptococcal meningitis
topic Online Only Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561241/
https://www.ncbi.nlm.nih.gov/pubmed/33051650
http://dx.doi.org/10.1093/cid/ciaa1544
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