Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh

Secretor status controls mucosal histo–blood group antigen expression and is associated with susceptibility to rotavirus (RV) diarrhea, with nonsecretors less susceptible to symptomatic infection. The role of breast milk secretor status on oral live-attenuated RV vaccine response in breastfed infant...

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Autores principales: Williams, Frank B, Kader, Abdul, Colgate, E Ross, Dickson, Dorothy M, Carmolli, Marya, Uddin, Muhammad Ikhtear, Sharmin, Salma, Islam, Shahidul, Bhuiyan, Taufiqur Rahman, Alam, Masud, Nayak, Uma, Mychaleckyj, Josyf C, Petri, William A, Haque, Rashidul, Qadri, Firdausi, Kirkpatrick, Beth D, Lee, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561252/
https://www.ncbi.nlm.nih.gov/pubmed/32157282
http://dx.doi.org/10.1093/infdis/jiaa101
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author Williams, Frank B
Kader, Abdul
Colgate, E Ross
Dickson, Dorothy M
Carmolli, Marya
Uddin, Muhammad Ikhtear
Sharmin, Salma
Islam, Shahidul
Bhuiyan, Taufiqur Rahman
Alam, Masud
Nayak, Uma
Mychaleckyj, Josyf C
Petri, William A
Haque, Rashidul
Qadri, Firdausi
Kirkpatrick, Beth D
Lee, Benjamin
author_facet Williams, Frank B
Kader, Abdul
Colgate, E Ross
Dickson, Dorothy M
Carmolli, Marya
Uddin, Muhammad Ikhtear
Sharmin, Salma
Islam, Shahidul
Bhuiyan, Taufiqur Rahman
Alam, Masud
Nayak, Uma
Mychaleckyj, Josyf C
Petri, William A
Haque, Rashidul
Qadri, Firdausi
Kirkpatrick, Beth D
Lee, Benjamin
author_sort Williams, Frank B
collection PubMed
description Secretor status controls mucosal histo–blood group antigen expression and is associated with susceptibility to rotavirus (RV) diarrhea, with nonsecretors less susceptible to symptomatic infection. The role of breast milk secretor status on oral live-attenuated RV vaccine response in breastfed infants has not been explored. In a monovalent G1P[8] RV vaccine (Rotarix) trial in Bangladesh, RV-specific plasma immunoglobulin A antibody seroconversion rates were higher among infants of maternal nonsecretors (39%) than infants of maternal secretors (23%; P = .001). Maternal status remained a significant predictor when correcting for infant status (P = .002). Maternal secretor status should be considered when interpreting oral RV vaccine responses in low- and middle-income settings. Clinical Trials Registration. NCT01375647.
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spelling pubmed-85612522021-11-03 Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh Williams, Frank B Kader, Abdul Colgate, E Ross Dickson, Dorothy M Carmolli, Marya Uddin, Muhammad Ikhtear Sharmin, Salma Islam, Shahidul Bhuiyan, Taufiqur Rahman Alam, Masud Nayak, Uma Mychaleckyj, Josyf C Petri, William A Haque, Rashidul Qadri, Firdausi Kirkpatrick, Beth D Lee, Benjamin J Infect Dis Major Articles and Brief Reports Secretor status controls mucosal histo–blood group antigen expression and is associated with susceptibility to rotavirus (RV) diarrhea, with nonsecretors less susceptible to symptomatic infection. The role of breast milk secretor status on oral live-attenuated RV vaccine response in breastfed infants has not been explored. In a monovalent G1P[8] RV vaccine (Rotarix) trial in Bangladesh, RV-specific plasma immunoglobulin A antibody seroconversion rates were higher among infants of maternal nonsecretors (39%) than infants of maternal secretors (23%; P = .001). Maternal status remained a significant predictor when correcting for infant status (P = .002). Maternal secretor status should be considered when interpreting oral RV vaccine responses in low- and middle-income settings. Clinical Trials Registration. NCT01375647. Oxford University Press 2020-03-11 /pmc/articles/PMC8561252/ /pubmed/32157282 http://dx.doi.org/10.1093/infdis/jiaa101 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Williams, Frank B
Kader, Abdul
Colgate, E Ross
Dickson, Dorothy M
Carmolli, Marya
Uddin, Muhammad Ikhtear
Sharmin, Salma
Islam, Shahidul
Bhuiyan, Taufiqur Rahman
Alam, Masud
Nayak, Uma
Mychaleckyj, Josyf C
Petri, William A
Haque, Rashidul
Qadri, Firdausi
Kirkpatrick, Beth D
Lee, Benjamin
Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh
title Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh
title_full Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh
title_fullStr Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh
title_full_unstemmed Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh
title_short Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh
title_sort maternal secretor status affects oral rotavirus vaccine response in breastfed infants in bangladesh
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561252/
https://www.ncbi.nlm.nih.gov/pubmed/32157282
http://dx.doi.org/10.1093/infdis/jiaa101
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