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Investigation of mechanisms responsible for decreased susceptibility of aztreonam/avibactam activity in clinical isolates of Enterobacterales collected in Europe, Asia and Latin America in 2019

BACKGROUND: The combination aztreonam/avibactam is currently under Phase 3 trials for the treatment of serious infections caused by Gram-negative bacteria including those with MBLs. OBJECTIVES: To investigate the resistance mechanisms in Enterobacterales exhibiting aztreonam/avibactam MICs of ≥4 mg/...

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Detalles Bibliográficos
Autores principales:	Mendes, Rodrigo E, Doyle, Timothy B, Streit, Jennifer M, Arhin, Francis F, Sader, Helio S, Castanheira, Mariana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561256/ https://www.ncbi.nlm.nih.gov/pubmed/34436603 http://dx.doi.org/10.1093/jac/dkab279

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