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Prevalence of gp160 polymorphisms known to be related to decreased susceptibility to temsavir in different subtypes of HIV-1 in the Los Alamos National Laboratory HIV Sequence Database

BACKGROUND: Fostemsavir, a prodrug of the gp120-directed attachment inhibitor temsavir, is indicated for use in heavily treatment-experienced individuals with MDR HIV-1. Reduced susceptibility to temsavir in the clinic maps to discrete changes at amino acid positions in gp160: S375, M426, M434 and M...

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Detalles Bibliográficos
Autores principales:	Gartland, Margaret, Arnoult, Eric, Foley, Brian T, Lataillade, Max, Ackerman, Peter, Llamoso, Cyril, Krystal, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561262/ https://www.ncbi.nlm.nih.gov/pubmed/34297843 http://dx.doi.org/10.1093/jac/dkab257

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