Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations

Somatic mutations in genes coding for splicing factors, e.g., SF3B1, U2AF1, SRSF2, and others are found in approximately 50% of patients with myelodysplastic syndromes (MDS). These mutations have been predicted to frequently occur early in the mutational hierarchy of the disease, therefore, making t...

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Detalles Bibliográficos
Autores principales: Flach, Johanna, Jann, Johann-Christoph, Knaflic, Antje, Riabov, Vladimir, Streuer, Alexander, Altrock, Eva, Xu, Qingyu, Schmitt, Nanni, Obländer, Julia, Nowak, Verena, Danner, Justine, Mehralivand, Arwin, Hofmann, Franziska, Palme, Iris, Jawhar, Ahmed, Wuchter, Patrick, Metzgeroth, Georgia, Nolte, Florian, Hofmann, Wolf-Karsten, Nowak, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561278/
https://www.ncbi.nlm.nih.gov/pubmed/33054116
http://dx.doi.org/10.3324/haematol.2020.254193

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