Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitro

Intraluminal thrombus formation precipitates conditions such as acute myocardial infarction and disturbs local blood flow resulting in areas of rapidly changing blood flow velocities and steep gradients of blood shear rate. Shear rate gradients are known to be pro-thrombotic with an important role f...

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Detalles Bibliográficos
Autores principales: Hoefer, Thomas, Rana, Akshita, Niego, Be’eri, Jagdale, Shweta, Albers, Hugo J., Gardiner, Elizabeth E., Andrews, Robert K., van der Meer, Andries D., Hagemeyer, Christoph E., Westein, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561297/
https://www.ncbi.nlm.nih.gov/pubmed/33054112
http://dx.doi.org/10.3324/haematol.2020.250761

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