The Histidine Ammonia Lyase of Trypanosoma cruzi Is Involved in Acidocalcisome Alkalinization and Is Essential for Survival under Starvation Conditions

Trypanosoma cruzi, the agent of Chagas disease, accumulates polyphosphate (polyP) and Ca(2+) inside acidocalcisomes. The alkalinization of this organelle stimulates polyP hydrolysis and Ca(2+) release. Here, we report that histidine ammonia lyase (HAL), an enzyme that catalyzes histidine deamination...

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Detalles Bibliográficos
Autores principales: Mantilla, Brian S., Azevedo, Cristina, Denny, Paul W., Saiardi, Adolfo, Docampo, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561398/
https://www.ncbi.nlm.nih.gov/pubmed/34724827
http://dx.doi.org/10.1128/mBio.01981-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561398/
https://www.ncbi.nlm.nih.gov/pubmed/34724827
http://dx.doi.org/10.1128/mBio.01981-21

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