A regulatory phosphorylation site on Mec1 controls chromatin occupancy of RNA polymerases during replication stress

Upon replication stress, budding yeast checkpoint kinase Mec1(ATR) triggers the downregulation of transcription, thereby reducing the level of RNA polymerase (RNAP) on chromatin to facilitate replication fork progression. Here, we identify a hydroxyurea‐induced phosphorylation site on Mec1, Mec1‐S19...

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Detalles Bibliográficos
Autores principales: Hurst, Verena, Challa, Kiran, Jonas, Felix, Forey, Romain, Sack, Ragna, Seebacher, Jan, Schmid, Christoph D, Barkai, Naama, Shimada, Kenji, Gasser, Susan M, Poli, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561635/
https://www.ncbi.nlm.nih.gov/pubmed/34569643
http://dx.doi.org/10.15252/embj.2021108439

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