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Chaperone-Mediated Stress Sensing in Mycobacterium tuberculosis Enables Fast Activation and Sustained Response

Dynamical properties of gene regulatory networks are tuned to ensure bacterial survival. In mycobacteria, the MprAB-σ(E) network responds to the presence of stressors, such as surfactants that cause surface stress. Positive feedback loops in this network were previously predicted to cause hysteresis...

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Detalles Bibliográficos
Autores principales: Rao, Satyajit D., Datta, Pratik, Gennaro, Maria Laura, Igoshin, Oleg A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561658/
https://www.ncbi.nlm.nih.gov/pubmed/33594002
http://dx.doi.org/10.1128/mSystems.00979-20