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The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1

BACKGROUND: DLC1, a tumor suppressor gene that is downregulated in many cancer types by genetic and nongenetic mechanisms, encodes a protein whose RhoGAP and scaffolding activities contribute to its tumor suppressor functions. The role of the DLC1 START (StAR-related lipid transfer; DLC1-START) doma...

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Detalles Bibliográficos
Autores principales:	Sanchez-Solana, Beatriz, Wang, Dunrui, Qian, Xiaolan, Velayoudame, Parthibane, Simanshu, Dhirendra K., Acharya, Jairaj K., Lowy, Douglas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561924/ https://www.ncbi.nlm.nih.gov/pubmed/34727930 http://dx.doi.org/10.1186/s12943-021-01439-y

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