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Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis
BACKGROUND: Though cervical cancer is largely preventable, it is still the second most common female cancer globally and the leading cause of cancer deaths among females in African. Though many efforts have been done to study the burden of the disease in Ethiopia, primary studies examining the preva...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561933/ https://www.ncbi.nlm.nih.gov/pubmed/34724978 http://dx.doi.org/10.1186/s13643-021-01840-0 |
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author | Kasa, Ayele Semachew Dagget, Tadesse Beyene, Yeshiwork Dessie, Getnet Endalamaw, Aklilu Workineh, Yinager Ayalew, Emiru Zeleke, Balew Kerie, Sitotaw Mulat, Getasew Animaw, Worku |
author_facet | Kasa, Ayele Semachew Dagget, Tadesse Beyene, Yeshiwork Dessie, Getnet Endalamaw, Aklilu Workineh, Yinager Ayalew, Emiru Zeleke, Balew Kerie, Sitotaw Mulat, Getasew Animaw, Worku |
author_sort | Kasa, Ayele Semachew |
collection | PubMed |
description | BACKGROUND: Though cervical cancer is largely preventable, it is still the second most common female cancer globally and the leading cause of cancer deaths among females in African. Though many efforts have been done to study the burden of the disease in Ethiopia, primary studies examining the prevalence of precancerous cervical lesions are fragmented. Hence, this systematic review and meta-analysis is aimed at estimating the pooled prevalence of precancerous cervical lesion and its trends in Ethiopia. METHODS: This systematic review and meta-analysis was conducted using the following electronic databases. PubMed, Web of Science, SCOPUS, Science Direct, Google Scholar, African Index Medicus (AIM), African Journals Online databases, and Addis Ababa and Bahir Dar Universities research repositories were searched following the Preferred Items for Systematic Review and Meta-analysis (PRISMA) Guideline. STATA 15 statistical software was used to analyze the data. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) quality appraisal tool for meta-analysis. Heterogeneity between studies was assessed using the Cochrane Q test and I(2) test statistics based on the random effects model. A random effects model was computed to estimate the pooled prevalence of precancerous cervical lesion in Ethiopia. Finally, the trend of precancerous cervical lesion in the country was presented. RESULT: Seventeen studies with a total of 26,112 participants were included in the analysis. The pooled prevalence of precancerous cervical lesion was 15.16 (95% CI 10.16–19.70). The subgroup analysis by region showed the highest prevalence of precancerous cervical lesion at the Southern Nations and Nationalities Peoples Region (19.65%; 95% CI 15.51–23.80). The trend of precancerous cervical lesion prevalence showed an increased pattern over time. CONCLUSION: Approximately one among six of the study participants had precancerous cervical lesion. The trend also showed that there is still an increasing precancerous cervical lesion in Ethiopia. Best practices in achieving high vaccination coverage shall be informed by practices in other successful countries. |
format | Online Article Text |
id | pubmed-8561933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85619332021-11-03 Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis Kasa, Ayele Semachew Dagget, Tadesse Beyene, Yeshiwork Dessie, Getnet Endalamaw, Aklilu Workineh, Yinager Ayalew, Emiru Zeleke, Balew Kerie, Sitotaw Mulat, Getasew Animaw, Worku Syst Rev Research BACKGROUND: Though cervical cancer is largely preventable, it is still the second most common female cancer globally and the leading cause of cancer deaths among females in African. Though many efforts have been done to study the burden of the disease in Ethiopia, primary studies examining the prevalence of precancerous cervical lesions are fragmented. Hence, this systematic review and meta-analysis is aimed at estimating the pooled prevalence of precancerous cervical lesion and its trends in Ethiopia. METHODS: This systematic review and meta-analysis was conducted using the following electronic databases. PubMed, Web of Science, SCOPUS, Science Direct, Google Scholar, African Index Medicus (AIM), African Journals Online databases, and Addis Ababa and Bahir Dar Universities research repositories were searched following the Preferred Items for Systematic Review and Meta-analysis (PRISMA) Guideline. STATA 15 statistical software was used to analyze the data. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) quality appraisal tool for meta-analysis. Heterogeneity between studies was assessed using the Cochrane Q test and I(2) test statistics based on the random effects model. A random effects model was computed to estimate the pooled prevalence of precancerous cervical lesion in Ethiopia. Finally, the trend of precancerous cervical lesion in the country was presented. RESULT: Seventeen studies with a total of 26,112 participants were included in the analysis. The pooled prevalence of precancerous cervical lesion was 15.16 (95% CI 10.16–19.70). The subgroup analysis by region showed the highest prevalence of precancerous cervical lesion at the Southern Nations and Nationalities Peoples Region (19.65%; 95% CI 15.51–23.80). The trend of precancerous cervical lesion prevalence showed an increased pattern over time. CONCLUSION: Approximately one among six of the study participants had precancerous cervical lesion. The trend also showed that there is still an increasing precancerous cervical lesion in Ethiopia. Best practices in achieving high vaccination coverage shall be informed by practices in other successful countries. BioMed Central 2021-11-01 /pmc/articles/PMC8561933/ /pubmed/34724978 http://dx.doi.org/10.1186/s13643-021-01840-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Kasa, Ayele Semachew Dagget, Tadesse Beyene, Yeshiwork Dessie, Getnet Endalamaw, Aklilu Workineh, Yinager Ayalew, Emiru Zeleke, Balew Kerie, Sitotaw Mulat, Getasew Animaw, Worku Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis |
title | Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis |
title_full | Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis |
title_fullStr | Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis |
title_full_unstemmed | Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis |
title_short | Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis |
title_sort | precancerous cervical lesion in ethiopia: systematic review and meta-analysis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561933/ https://www.ncbi.nlm.nih.gov/pubmed/34724978 http://dx.doi.org/10.1186/s13643-021-01840-0 |
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