Neonatal abstinence syndrome is a potential cause of low TREC copy number

Severe combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor excision circles (TRECs) to screen for SCID in newborns, but false positives may be seen in sev...

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Detalles Bibliográficos
Autores principales: Adatia, Adil, Ling, Ling, Chakraborty, Pranesh, Brick, Lauren, Brager, Rae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561999/
https://www.ncbi.nlm.nih.gov/pubmed/34727967
http://dx.doi.org/10.1186/s13223-021-00617-3
Descripción
Sumario:Severe combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor excision circles (TRECs) to screen for SCID in newborns, but false positives may be seen in several conditions. We report 3 newborns with neonatal abstinence syndrome who presented with decreased TREC copy number.

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