Neonatal abstinence syndrome is a potential cause of low TREC copy number

Severe combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor excision circles (TRECs) to screen for SCID in newborns, but false positives may be seen in sev...

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Autores principales: Adatia, Adil, Ling, Ling, Chakraborty, Pranesh, Brick, Lauren, Brager, Rae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561999/
https://www.ncbi.nlm.nih.gov/pubmed/34727967
http://dx.doi.org/10.1186/s13223-021-00617-3
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author Adatia, Adil
Ling, Ling
Chakraborty, Pranesh
Brick, Lauren
Brager, Rae
author_facet Adatia, Adil
Ling, Ling
Chakraborty, Pranesh
Brick, Lauren
Brager, Rae
author_sort Adatia, Adil
collection PubMed
description Severe combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor excision circles (TRECs) to screen for SCID in newborns, but false positives may be seen in several conditions. We report 3 newborns with neonatal abstinence syndrome who presented with decreased TREC copy number.
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spelling pubmed-85619992021-11-03 Neonatal abstinence syndrome is a potential cause of low TREC copy number Adatia, Adil Ling, Ling Chakraborty, Pranesh Brick, Lauren Brager, Rae Allergy Asthma Clin Immunol Letter to the Editor Severe combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor excision circles (TRECs) to screen for SCID in newborns, but false positives may be seen in several conditions. We report 3 newborns with neonatal abstinence syndrome who presented with decreased TREC copy number. BioMed Central 2021-11-02 /pmc/articles/PMC8561999/ /pubmed/34727967 http://dx.doi.org/10.1186/s13223-021-00617-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Adatia, Adil
Ling, Ling
Chakraborty, Pranesh
Brick, Lauren
Brager, Rae
Neonatal abstinence syndrome is a potential cause of low TREC copy number
title Neonatal abstinence syndrome is a potential cause of low TREC copy number
title_full Neonatal abstinence syndrome is a potential cause of low TREC copy number
title_fullStr Neonatal abstinence syndrome is a potential cause of low TREC copy number
title_full_unstemmed Neonatal abstinence syndrome is a potential cause of low TREC copy number
title_short Neonatal abstinence syndrome is a potential cause of low TREC copy number
title_sort neonatal abstinence syndrome is a potential cause of low trec copy number
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561999/
https://www.ncbi.nlm.nih.gov/pubmed/34727967
http://dx.doi.org/10.1186/s13223-021-00617-3
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