Ventilatory constraint is more severe in walking than cycling in patients with COPD()

Due to its effectivity in assessing functional capacity and adding prognostic information to the staging of chronic obstructive pulmonary disease (COPD) patients, the 6-min walk test (6MWT) is extensively used in clinical evaluation. Currently, there is little information about the physiological response this test elicits in patients, especially when compared to cardiopulmonary exercise test (CPET). The aim of the study was to compare ventilatory and metabolic responses between these tests commonly used for the assessment of clinical outcome. A group of 20 patients with moderate to very severe COPD were tested for their pulmonary function (flow-volume curve, static lung volumes), occlusion mouth pressures and breath-by-breath measurement of flow, volumes, and oxygen (O(2)) and carbon dioxide (CO(2)) concentration during the 6MWT and CPET. All parameters measured during both exercise tests were assessed over the throughout of the tests and compared between each other at specified time points. Serially measured inspiratory vital capacity (IVC) decreased more rapidly and extensively during the walk-test (p ​< ​0,0001). This was accompanied by a limited increase in tidal volume (V(T)) and minute ventilation (V(E)), which were significantly lower in the course of the 6MWT (p ​= ​0,0003 and p ​= ​0,0097, respectively). We also noticed a significant decrease in hemoglobin oxygen saturation (SpO(2)) during the 6MWT which was correlated to percent decrease in IVC (p ​= ​0,0206). Over the course of the 6MWT, oxygen consumption (VO(2)) and V(T) reached plateau within 2 ​min, while carbon dioxide production (VCO(2)) and V(E) within 3 ​min. During CPET, VO(2), VCO(2) and V(E) rose continuously, while V(T) reached plateau within 4 ​min. The 6MWT seems to be a rather endurance-based test associated with more pronounced dynamic lung hyperinflation and mechanical constraint of ventilation in comparison to cycling.