Percutaneous microwave ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma with macrovascular invasion or extrahepatic metastases

OBJECTIVE: To evaluate the safety and efficacy of percutaneous microwave ablation (MWA) combined with simultaneous transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI) or extrahepatic metastases (EHM). METHODS: Between Augu...

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Autores principales: Wu, Mengfei, Gao, Shanshan, Song, Huadan, Zhang, Zihan, Zheng, Zhiyuan, Yan, Zhiping, Wang, Xiaolin, Wang, Jianhua, Liu, Lingxiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562208/
https://www.ncbi.nlm.nih.gov/pubmed/34805873
http://dx.doi.org/10.1016/j.jimed.2019.07.003
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author Wu, Mengfei
Gao, Shanshan
Song, Huadan
Zhang, Zihan
Zheng, Zhiyuan
Yan, Zhiping
Wang, Xiaolin
Wang, Jianhua
Liu, Lingxiao
author_facet Wu, Mengfei
Gao, Shanshan
Song, Huadan
Zhang, Zihan
Zheng, Zhiyuan
Yan, Zhiping
Wang, Xiaolin
Wang, Jianhua
Liu, Lingxiao
author_sort Wu, Mengfei
collection PubMed
description OBJECTIVE: To evaluate the safety and efficacy of percutaneous microwave ablation (MWA) combined with simultaneous transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI) or extrahepatic metastases (EHM). METHODS: Between August 2012 and April 2017, 101 patients with MVI/EHM of HCC underwent percutaneous MWA combined with simultaneous TACE at our center. The clinical data were collected and analyzed for survival and prognostic factors. RESULTS: The mean follow-up time was 23.6 ± 14.7 months. One patient had grade 3 complications, and the median overall survival was 12.0 months (95% confidence interval 9.7–14.3). Multivariate analysis showed that Child-Pugh class, serum alpha-fetoprotein level, and Eastern Cooperative Oncology Group performance status were independent factors of survival. CONCLUSION: Our results suggest that percutaneous MWA combined with simultaneous TACE is a safe and effective treatment for HCC with MVI/EHM.
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spelling pubmed-85622082021-11-19 Percutaneous microwave ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma with macrovascular invasion or extrahepatic metastases Wu, Mengfei Gao, Shanshan Song, Huadan Zhang, Zihan Zheng, Zhiyuan Yan, Zhiping Wang, Xiaolin Wang, Jianhua Liu, Lingxiao J Interv Med Article OBJECTIVE: To evaluate the safety and efficacy of percutaneous microwave ablation (MWA) combined with simultaneous transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI) or extrahepatic metastases (EHM). METHODS: Between August 2012 and April 2017, 101 patients with MVI/EHM of HCC underwent percutaneous MWA combined with simultaneous TACE at our center. The clinical data were collected and analyzed for survival and prognostic factors. RESULTS: The mean follow-up time was 23.6 ± 14.7 months. One patient had grade 3 complications, and the median overall survival was 12.0 months (95% confidence interval 9.7–14.3). Multivariate analysis showed that Child-Pugh class, serum alpha-fetoprotein level, and Eastern Cooperative Oncology Group performance status were independent factors of survival. CONCLUSION: Our results suggest that percutaneous MWA combined with simultaneous TACE is a safe and effective treatment for HCC with MVI/EHM. KeAi Publishing 2019-07-30 /pmc/articles/PMC8562208/ /pubmed/34805873 http://dx.doi.org/10.1016/j.jimed.2019.07.003 Text en © 2019 Shanghai Journal of Interventional Medicine Press. Production and hosting by Elsevier B.V. on behalf of KeAi. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wu, Mengfei
Gao, Shanshan
Song, Huadan
Zhang, Zihan
Zheng, Zhiyuan
Yan, Zhiping
Wang, Xiaolin
Wang, Jianhua
Liu, Lingxiao
Percutaneous microwave ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma with macrovascular invasion or extrahepatic metastases
title Percutaneous microwave ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma with macrovascular invasion or extrahepatic metastases
title_full Percutaneous microwave ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma with macrovascular invasion or extrahepatic metastases
title_fullStr Percutaneous microwave ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma with macrovascular invasion or extrahepatic metastases
title_full_unstemmed Percutaneous microwave ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma with macrovascular invasion or extrahepatic metastases
title_short Percutaneous microwave ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma with macrovascular invasion or extrahepatic metastases
title_sort percutaneous microwave ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma with macrovascular invasion or extrahepatic metastases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562208/
https://www.ncbi.nlm.nih.gov/pubmed/34805873
http://dx.doi.org/10.1016/j.jimed.2019.07.003
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