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Effects of repeated blood donation on iron status of blood donors in Zimbabwe: A cross‐sectional study

INTRODUCTION: Iron deficiency is a major complication of repeated blood donation. However, most of the blood screening methods employed by blood collection agents do not include iron status markers, leading to possible subclinical iron deficiency. The aim of this study was to evaluate the effects of...

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Autores principales: Vhanda, Donald, Chinowaita, Frank, Nkomo, Sisodwa, Timire, Collins, Kouamou, Vinie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562310/
https://www.ncbi.nlm.nih.gov/pubmed/34754947
http://dx.doi.org/10.1002/hsr2.426
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author Vhanda, Donald
Chinowaita, Frank
Nkomo, Sisodwa
Timire, Collins
Kouamou, Vinie
author_facet Vhanda, Donald
Chinowaita, Frank
Nkomo, Sisodwa
Timire, Collins
Kouamou, Vinie
author_sort Vhanda, Donald
collection PubMed
description INTRODUCTION: Iron deficiency is a major complication of repeated blood donation. However, most of the blood screening methods employed by blood collection agents do not include iron status markers, leading to possible subclinical iron deficiency. The aim of this study was to evaluate the effects of repeated blood donation on the iron status of this vulnerable population in Zimbabwe. METHODS: All donors were categorized into groups based on number of donations made in the previous 2‐year period prior to enrolment into the study. Serum iron, total iron‐binding capacity (TIBC), and ferritin were analyzed on automated chemistry analyzers while transferrin saturation (TSAT) was calculated. The Wilcoxon rank‐sum and ANOVA tests were used to assess the variation of iron profiles by gender and frequency of donations. All data analysis was performed using Stata software v13. RESULTS: Study participants included 170 repeat donors and 20 first‐time blood donors. The median (IQR) age was 23 (19‐27) years, while the majority were males 57% (n = 109/190). The overall prevalence of iron deficiency and reduced iron stores was 12.6% and 38.9%, respectively. There were statistically significant differences between males and females in all the iron status parameters (P < .05). TIBC increased with number of donations, while iron, ferritin, and TSAT decreased with increased number of donations. CONCLUSION: A high proportion of blood donors had iron deficiency despite being eligible to donate. Repeated blood donation may lead to substantial reduction in iron stores among blood donors. Inclusion of iron biochemical markers may enhance proper screening and monitoring of blood donors in Zimbabwe to prevent development of iron deficiency anemia.
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spelling pubmed-85623102021-11-08 Effects of repeated blood donation on iron status of blood donors in Zimbabwe: A cross‐sectional study Vhanda, Donald Chinowaita, Frank Nkomo, Sisodwa Timire, Collins Kouamou, Vinie Health Sci Rep Research Articles INTRODUCTION: Iron deficiency is a major complication of repeated blood donation. However, most of the blood screening methods employed by blood collection agents do not include iron status markers, leading to possible subclinical iron deficiency. The aim of this study was to evaluate the effects of repeated blood donation on the iron status of this vulnerable population in Zimbabwe. METHODS: All donors were categorized into groups based on number of donations made in the previous 2‐year period prior to enrolment into the study. Serum iron, total iron‐binding capacity (TIBC), and ferritin were analyzed on automated chemistry analyzers while transferrin saturation (TSAT) was calculated. The Wilcoxon rank‐sum and ANOVA tests were used to assess the variation of iron profiles by gender and frequency of donations. All data analysis was performed using Stata software v13. RESULTS: Study participants included 170 repeat donors and 20 first‐time blood donors. The median (IQR) age was 23 (19‐27) years, while the majority were males 57% (n = 109/190). The overall prevalence of iron deficiency and reduced iron stores was 12.6% and 38.9%, respectively. There were statistically significant differences between males and females in all the iron status parameters (P < .05). TIBC increased with number of donations, while iron, ferritin, and TSAT decreased with increased number of donations. CONCLUSION: A high proportion of blood donors had iron deficiency despite being eligible to donate. Repeated blood donation may lead to substantial reduction in iron stores among blood donors. Inclusion of iron biochemical markers may enhance proper screening and monitoring of blood donors in Zimbabwe to prevent development of iron deficiency anemia. John Wiley and Sons Inc. 2021-11-02 /pmc/articles/PMC8562310/ /pubmed/34754947 http://dx.doi.org/10.1002/hsr2.426 Text en © 2021 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Vhanda, Donald
Chinowaita, Frank
Nkomo, Sisodwa
Timire, Collins
Kouamou, Vinie
Effects of repeated blood donation on iron status of blood donors in Zimbabwe: A cross‐sectional study
title Effects of repeated blood donation on iron status of blood donors in Zimbabwe: A cross‐sectional study
title_full Effects of repeated blood donation on iron status of blood donors in Zimbabwe: A cross‐sectional study
title_fullStr Effects of repeated blood donation on iron status of blood donors in Zimbabwe: A cross‐sectional study
title_full_unstemmed Effects of repeated blood donation on iron status of blood donors in Zimbabwe: A cross‐sectional study
title_short Effects of repeated blood donation on iron status of blood donors in Zimbabwe: A cross‐sectional study
title_sort effects of repeated blood donation on iron status of blood donors in zimbabwe: a cross‐sectional study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562310/
https://www.ncbi.nlm.nih.gov/pubmed/34754947
http://dx.doi.org/10.1002/hsr2.426
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