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Acute perioperative hyperlactatemia in oncoplastic reconstructive surgeries: What is the significance?

BACKGROUND AND AIMS: We aim to study the significance of intraoperative hyperlactatemia in reconstructive oncoplastic surgery. MATERIAL AND METHODS: A retrospective observational study was conducted on a cohort of patients who underwent reconstructive oncoplastic surgery with free flap for oral canc...

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Autores principales: Roy, Preety M., Bharti, Kamal, Sinha, Sudha, Khanna, Sangeeta, Mehta, Yatin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562435/
https://www.ncbi.nlm.nih.gov/pubmed/34759554
http://dx.doi.org/10.4103/joacp.JOACP_297_19
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author Roy, Preety M.
Bharti, Kamal
Sinha, Sudha
Khanna, Sangeeta
Mehta, Yatin
author_facet Roy, Preety M.
Bharti, Kamal
Sinha, Sudha
Khanna, Sangeeta
Mehta, Yatin
author_sort Roy, Preety M.
collection PubMed
description BACKGROUND AND AIMS: We aim to study the significance of intraoperative hyperlactatemia in reconstructive oncoplastic surgery. MATERIAL AND METHODS: A retrospective observational study was conducted on a cohort of patients who underwent reconstructive oncoplastic surgery with free flap for oral cancer over a 6-month period. The study population was divided into two groups based on peak lactate levels. Group N with peak lactate level less than 2 mmol/L and Group H peak lactate level more than 2 mmol/L. The various parameter studied were patient's comorbidities; intraoperative events (vasopressor requirement, blood transfusion, and duration of surgery); postoperative parameters including the need for re- exploration and duration of stay in hospital and intensive care unit. RESULTS: The study demonstrates that intraoperative rise of lactate was not influenced by comorbidities. None of the intraoperative parameters studied influenced the lactate levels. Baseline lactate level was found to correlate with peak lactate level intraoperatively. But it was observed that there was normalization of lactate level within 24 hours postoperatively in both the groups. There was no difference in outcome parameters in the two groups. CONCLUSION: Intraoperative hyperlactatemia is not a significant prognostic factor for outcome in oncoplastic reconstructive surgery.
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spelling pubmed-85624352021-11-09 Acute perioperative hyperlactatemia in oncoplastic reconstructive surgeries: What is the significance? Roy, Preety M. Bharti, Kamal Sinha, Sudha Khanna, Sangeeta Mehta, Yatin J Anaesthesiol Clin Pharmacol Original Article BACKGROUND AND AIMS: We aim to study the significance of intraoperative hyperlactatemia in reconstructive oncoplastic surgery. MATERIAL AND METHODS: A retrospective observational study was conducted on a cohort of patients who underwent reconstructive oncoplastic surgery with free flap for oral cancer over a 6-month period. The study population was divided into two groups based on peak lactate levels. Group N with peak lactate level less than 2 mmol/L and Group H peak lactate level more than 2 mmol/L. The various parameter studied were patient's comorbidities; intraoperative events (vasopressor requirement, blood transfusion, and duration of surgery); postoperative parameters including the need for re- exploration and duration of stay in hospital and intensive care unit. RESULTS: The study demonstrates that intraoperative rise of lactate was not influenced by comorbidities. None of the intraoperative parameters studied influenced the lactate levels. Baseline lactate level was found to correlate with peak lactate level intraoperatively. But it was observed that there was normalization of lactate level within 24 hours postoperatively in both the groups. There was no difference in outcome parameters in the two groups. CONCLUSION: Intraoperative hyperlactatemia is not a significant prognostic factor for outcome in oncoplastic reconstructive surgery. Wolters Kluwer - Medknow 2021 2021-10-12 /pmc/articles/PMC8562435/ /pubmed/34759554 http://dx.doi.org/10.4103/joacp.JOACP_297_19 Text en Copyright: © 2021 Journal of Anaesthesiology Clinical Pharmacology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Roy, Preety M.
Bharti, Kamal
Sinha, Sudha
Khanna, Sangeeta
Mehta, Yatin
Acute perioperative hyperlactatemia in oncoplastic reconstructive surgeries: What is the significance?
title Acute perioperative hyperlactatemia in oncoplastic reconstructive surgeries: What is the significance?
title_full Acute perioperative hyperlactatemia in oncoplastic reconstructive surgeries: What is the significance?
title_fullStr Acute perioperative hyperlactatemia in oncoplastic reconstructive surgeries: What is the significance?
title_full_unstemmed Acute perioperative hyperlactatemia in oncoplastic reconstructive surgeries: What is the significance?
title_short Acute perioperative hyperlactatemia in oncoplastic reconstructive surgeries: What is the significance?
title_sort acute perioperative hyperlactatemia in oncoplastic reconstructive surgeries: what is the significance?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562435/
https://www.ncbi.nlm.nih.gov/pubmed/34759554
http://dx.doi.org/10.4103/joacp.JOACP_297_19
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