BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™) induces tumor localized CD137 agonism

BACKGROUND: CD137 (4-1BB) is an immune costimulatory receptor with high therapeutic potential in cancer. We are creating tumor target-dependent CD137 agonists using a novel chemical approach based on fully synthetic constrained bicyclic peptide (Bicycle®) technology. Nectin-4 is overexpressed in mul...

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Detalles Bibliográficos
Autores principales: Hurov, Kristen, Lahdenranta, Johanna, Upadhyaya, Punit, Haines, Eric, Cohen, Heather, Repash, Elizabeth, Kanakia, Drasti, Ma, Jun, Kristensson, Julia, You, Fanglei, Campbell, Carly, Witty, David, Kelly, Mike, Blakemore, Stephen, Jeffrey, Phil, McDonnell, Kevin, Brandish, Philip, Keen, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562524/
https://www.ncbi.nlm.nih.gov/pubmed/34725211
http://dx.doi.org/10.1136/jitc-2021-002883

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