Variations in cell-surface ACE2 levels alter direct binding of SARS-CoV-2 Spike protein and viral infectivity: Implications for measuring Spike protein interactions with animal ACE2 orthologs

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, the most severe pandemic in a century. The virus gains access to host cells when the viral Spike protein (S-protein) binds to the host cell-surface receptor angiotensin-converting enzyme 2 (ACE2). St...

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Detalles Bibliográficos
Autores principales: Kazemi, Soheila, López-Muñoz, Alberto Domingo, Hollý, Jaroslav, Jin, Ling, Yewdell, Jonathan W., Dolan, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562541/
https://www.ncbi.nlm.nih.gov/pubmed/34729559
http://dx.doi.org/10.1101/2021.10.21.465386
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