Cargando…
Associations between SARS-CoV-2 variants and risk of COVID-19 hospitalization among confirmed cases in Washington State: a retrospective cohort study
BACKGROUND: The COVID-19 pandemic is dominated by variant viruses; the resulting impact on disease severity remains unclear. Using a retrospective cohort study, we assessed the hospitalization risk following infection with seven SARS-CoV-2 variants. METHODS: Our study includes individuals with posit...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562551/ https://www.ncbi.nlm.nih.gov/pubmed/34729567 http://dx.doi.org/10.1101/2021.09.29.21264272 |
_version_ | 1784593279720882176 |
---|---|
author | Paredes, Miguel I. Lunn, Stephanie M. Famulare, Michael Frisbie, Lauren A. Painter, Ian Burstein, Roy Roychoudhury, Pavitra Xie, Hong Mohamed Bakhash, Shah A. Perez, Ricardo Lukes, Maria Ellis, Sean Sathees, Saraswathi Mathias, Patrick C. Greninger, Alexander Starita, Lea M. Frazar, Chris D. Ryke, Erica Zhong, Weizhi Gamboa, Luis Threlkeld, Machiko Lee, Jover McDermot, Evan Truong, Melissa Nickerson, Deborah A. Bates, Daniel L. Hartman, Matthew E. Haugen, Eric Nguyen, Truong N. Richards, Joshua D. Rodriguez, Jacob L. Stamatoyannopoulos, John A. Thorland, Eric Melly, Geoff Dykema, Philip E. MacKellar, Drew C. Gray, Hannah K. Singh, Avi Peterson, JohnAric M. Russell, Denny Torres, Laura Marcela Lindquist, Scott Bedford, Trevor Allen, Krisandra J. Oltean, Hanna N. |
author_facet | Paredes, Miguel I. Lunn, Stephanie M. Famulare, Michael Frisbie, Lauren A. Painter, Ian Burstein, Roy Roychoudhury, Pavitra Xie, Hong Mohamed Bakhash, Shah A. Perez, Ricardo Lukes, Maria Ellis, Sean Sathees, Saraswathi Mathias, Patrick C. Greninger, Alexander Starita, Lea M. Frazar, Chris D. Ryke, Erica Zhong, Weizhi Gamboa, Luis Threlkeld, Machiko Lee, Jover McDermot, Evan Truong, Melissa Nickerson, Deborah A. Bates, Daniel L. Hartman, Matthew E. Haugen, Eric Nguyen, Truong N. Richards, Joshua D. Rodriguez, Jacob L. Stamatoyannopoulos, John A. Thorland, Eric Melly, Geoff Dykema, Philip E. MacKellar, Drew C. Gray, Hannah K. Singh, Avi Peterson, JohnAric M. Russell, Denny Torres, Laura Marcela Lindquist, Scott Bedford, Trevor Allen, Krisandra J. Oltean, Hanna N. |
author_sort | Paredes, Miguel I. |
collection | PubMed |
description | BACKGROUND: The COVID-19 pandemic is dominated by variant viruses; the resulting impact on disease severity remains unclear. Using a retrospective cohort study, we assessed the hospitalization risk following infection with seven SARS-CoV-2 variants. METHODS: Our study includes individuals with positive SARS-CoV-2 RT-PCR in the Washington Disease Reporting System with available viral genome data, from December 1, 2020 to January 14, 2022. The analysis was restricted to cases with specimens collected through sentinel surveillance. Using a Cox proportional hazards model with mixed effects, we estimated hazard ratios (HR) for hospitalization risk following infection with a variant, adjusting for age, sex, calendar week, and vaccination. FINDINGS: 58,848 cases were sequenced through sentinel surveillance, of which 1705 (2.9%) were hospitalized due to COVID-19. Higher hospitalization risk was found for infections with Gamma (HR 3.20, 95%CI 2.40–4.26), Beta (HR 2.85, 95%CI 1.56–5.23), Delta (HR 2.28 95%CI 1.56–3.34) or Alpha (HR 1.64, 95%CI 1.29–2.07) compared to infections with ancestral lineages; Omicron (HR 0.92, 95%CI 0.56–1.52) showed no significant difference in risk. Following Alpha, Gamma, or Delta infection, unvaccinated patients show higher hospitalization risk, while vaccinated patients show no significant difference in risk, both compared to unvaccinated, ancestral lineage cases. Hospitalization risk following Omicron infection is lower with vaccination. CONCLUSION: Infection with Alpha, Gamma, or Delta results in a higher hospitalization risk, with vaccination attenuating that risk. Our findings support hospital preparedness, vaccination, and genomic surveillance. |
format | Online Article Text |
id | pubmed-8562551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-85625512021-11-03 Associations between SARS-CoV-2 variants and risk of COVID-19 hospitalization among confirmed cases in Washington State: a retrospective cohort study Paredes, Miguel I. Lunn, Stephanie M. Famulare, Michael Frisbie, Lauren A. Painter, Ian Burstein, Roy Roychoudhury, Pavitra Xie, Hong Mohamed Bakhash, Shah A. Perez, Ricardo Lukes, Maria Ellis, Sean Sathees, Saraswathi Mathias, Patrick C. Greninger, Alexander Starita, Lea M. Frazar, Chris D. Ryke, Erica Zhong, Weizhi Gamboa, Luis Threlkeld, Machiko Lee, Jover McDermot, Evan Truong, Melissa Nickerson, Deborah A. Bates, Daniel L. Hartman, Matthew E. Haugen, Eric Nguyen, Truong N. Richards, Joshua D. Rodriguez, Jacob L. Stamatoyannopoulos, John A. Thorland, Eric Melly, Geoff Dykema, Philip E. MacKellar, Drew C. Gray, Hannah K. Singh, Avi Peterson, JohnAric M. Russell, Denny Torres, Laura Marcela Lindquist, Scott Bedford, Trevor Allen, Krisandra J. Oltean, Hanna N. medRxiv Article BACKGROUND: The COVID-19 pandemic is dominated by variant viruses; the resulting impact on disease severity remains unclear. Using a retrospective cohort study, we assessed the hospitalization risk following infection with seven SARS-CoV-2 variants. METHODS: Our study includes individuals with positive SARS-CoV-2 RT-PCR in the Washington Disease Reporting System with available viral genome data, from December 1, 2020 to January 14, 2022. The analysis was restricted to cases with specimens collected through sentinel surveillance. Using a Cox proportional hazards model with mixed effects, we estimated hazard ratios (HR) for hospitalization risk following infection with a variant, adjusting for age, sex, calendar week, and vaccination. FINDINGS: 58,848 cases were sequenced through sentinel surveillance, of which 1705 (2.9%) were hospitalized due to COVID-19. Higher hospitalization risk was found for infections with Gamma (HR 3.20, 95%CI 2.40–4.26), Beta (HR 2.85, 95%CI 1.56–5.23), Delta (HR 2.28 95%CI 1.56–3.34) or Alpha (HR 1.64, 95%CI 1.29–2.07) compared to infections with ancestral lineages; Omicron (HR 0.92, 95%CI 0.56–1.52) showed no significant difference in risk. Following Alpha, Gamma, or Delta infection, unvaccinated patients show higher hospitalization risk, while vaccinated patients show no significant difference in risk, both compared to unvaccinated, ancestral lineage cases. Hospitalization risk following Omicron infection is lower with vaccination. CONCLUSION: Infection with Alpha, Gamma, or Delta results in a higher hospitalization risk, with vaccination attenuating that risk. Our findings support hospital preparedness, vaccination, and genomic surveillance. Cold Spring Harbor Laboratory 2022-02-16 /pmc/articles/PMC8562551/ /pubmed/34729567 http://dx.doi.org/10.1101/2021.09.29.21264272 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Paredes, Miguel I. Lunn, Stephanie M. Famulare, Michael Frisbie, Lauren A. Painter, Ian Burstein, Roy Roychoudhury, Pavitra Xie, Hong Mohamed Bakhash, Shah A. Perez, Ricardo Lukes, Maria Ellis, Sean Sathees, Saraswathi Mathias, Patrick C. Greninger, Alexander Starita, Lea M. Frazar, Chris D. Ryke, Erica Zhong, Weizhi Gamboa, Luis Threlkeld, Machiko Lee, Jover McDermot, Evan Truong, Melissa Nickerson, Deborah A. Bates, Daniel L. Hartman, Matthew E. Haugen, Eric Nguyen, Truong N. Richards, Joshua D. Rodriguez, Jacob L. Stamatoyannopoulos, John A. Thorland, Eric Melly, Geoff Dykema, Philip E. MacKellar, Drew C. Gray, Hannah K. Singh, Avi Peterson, JohnAric M. Russell, Denny Torres, Laura Marcela Lindquist, Scott Bedford, Trevor Allen, Krisandra J. Oltean, Hanna N. Associations between SARS-CoV-2 variants and risk of COVID-19 hospitalization among confirmed cases in Washington State: a retrospective cohort study |
title | Associations between SARS-CoV-2 variants and risk of COVID-19 hospitalization among confirmed cases in Washington State: a retrospective cohort study |
title_full | Associations between SARS-CoV-2 variants and risk of COVID-19 hospitalization among confirmed cases in Washington State: a retrospective cohort study |
title_fullStr | Associations between SARS-CoV-2 variants and risk of COVID-19 hospitalization among confirmed cases in Washington State: a retrospective cohort study |
title_full_unstemmed | Associations between SARS-CoV-2 variants and risk of COVID-19 hospitalization among confirmed cases in Washington State: a retrospective cohort study |
title_short | Associations between SARS-CoV-2 variants and risk of COVID-19 hospitalization among confirmed cases in Washington State: a retrospective cohort study |
title_sort | associations between sars-cov-2 variants and risk of covid-19 hospitalization among confirmed cases in washington state: a retrospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562551/ https://www.ncbi.nlm.nih.gov/pubmed/34729567 http://dx.doi.org/10.1101/2021.09.29.21264272 |
work_keys_str_mv | AT paredesmigueli associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT lunnstephaniem associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT famularemichael associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT frisbielaurena associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT painterian associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT bursteinroy associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT roychoudhurypavitra associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT xiehong associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT mohamedbakhashshaha associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT perezricardo associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT lukesmaria associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT ellissean associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT satheessaraswathi associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT mathiaspatrickc associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT greningeralexander associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT staritaleam associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT frazarchrisd associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT rykeerica associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT zhongweizhi associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT gamboaluis associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT threlkeldmachiko associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT leejover associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT mcdermotevan associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT truongmelissa associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT nickersondeboraha associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT batesdaniell associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT hartmanmatthewe associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT haugeneric associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT nguyentruongn associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT richardsjoshuad associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT rodriguezjacobl associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT stamatoyannopoulosjohna associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT thorlanderic associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT mellygeoff associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT dykemaphilipe associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT mackellardrewc associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT grayhannahk associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT singhavi associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT petersonjohnaricm associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT russelldenny associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT torreslauramarcela associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT lindquistscott associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT bedfordtrevor associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT allenkrisandraj associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy AT olteanhannan associationsbetweensarscov2variantsandriskofcovid19hospitalizationamongconfirmedcasesinwashingtonstatearetrospectivecohortstudy |