Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants

Nursing homes (NH) were among the first settings to receive COVID-19 vaccines in the United States, but staff vaccination coverage remains low at an average of 64%. Using an agent-based model, we examined the impact of community prevalence, the Delta variant, staff vaccination coverage, and boosters...

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Detalles Bibliográficos
Autores principales: Holmdahl, Inga, Kahn, Rebecca, Slifka, Kara Jacobs, Dooling, Kathleen, Slayton, Rachel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562554/
https://www.ncbi.nlm.nih.gov/pubmed/34729570
http://dx.doi.org/10.1101/2021.10.25.21265493
Descripción
Sumario:Nursing homes (NH) were among the first settings to receive COVID-19 vaccines in the United States, but staff vaccination coverage remains low at an average of 64%. Using an agent-based model, we examined the impact of community prevalence, the Delta variant, staff vaccination coverage, and boosters for residents on outbreak dynamics in nursing homes. We found that increased staff primary series coverage and high booster vaccine effectiveness (VE) in residents leads to fewer infections and that the cumulative incidence is highly dependent on community transmission. Despite high VE, high community transmission resulted in continued symptomatic infections in NHs.

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