Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants

Nursing homes (NH) were among the first settings to receive COVID-19 vaccines in the United States, but staff vaccination coverage remains low at an average of 64%. Using an agent-based model, we examined the impact of community prevalence, the Delta variant, staff vaccination coverage, and boosters...

Descripción completa

Detalles Bibliográficos
Autores principales: Holmdahl, Inga, Kahn, Rebecca, Slifka, Kara Jacobs, Dooling, Kathleen, Slayton, Rachel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562554/
https://www.ncbi.nlm.nih.gov/pubmed/34729570
http://dx.doi.org/10.1101/2021.10.25.21265493
_version_ 1784593280460128256
author Holmdahl, Inga
Kahn, Rebecca
Slifka, Kara Jacobs
Dooling, Kathleen
Slayton, Rachel B.
author_facet Holmdahl, Inga
Kahn, Rebecca
Slifka, Kara Jacobs
Dooling, Kathleen
Slayton, Rachel B.
author_sort Holmdahl, Inga
collection PubMed
description Nursing homes (NH) were among the first settings to receive COVID-19 vaccines in the United States, but staff vaccination coverage remains low at an average of 64%. Using an agent-based model, we examined the impact of community prevalence, the Delta variant, staff vaccination coverage, and boosters for residents on outbreak dynamics in nursing homes. We found that increased staff primary series coverage and high booster vaccine effectiveness (VE) in residents leads to fewer infections and that the cumulative incidence is highly dependent on community transmission. Despite high VE, high community transmission resulted in continued symptomatic infections in NHs.
format Online
Article
Text
id pubmed-8562554
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cold Spring Harbor Laboratory
record_format MEDLINE/PubMed
spelling pubmed-85625542021-11-03 Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants Holmdahl, Inga Kahn, Rebecca Slifka, Kara Jacobs Dooling, Kathleen Slayton, Rachel B. medRxiv Article Nursing homes (NH) were among the first settings to receive COVID-19 vaccines in the United States, but staff vaccination coverage remains low at an average of 64%. Using an agent-based model, we examined the impact of community prevalence, the Delta variant, staff vaccination coverage, and boosters for residents on outbreak dynamics in nursing homes. We found that increased staff primary series coverage and high booster vaccine effectiveness (VE) in residents leads to fewer infections and that the cumulative incidence is highly dependent on community transmission. Despite high VE, high community transmission resulted in continued symptomatic infections in NHs. Cold Spring Harbor Laboratory 2021-10-26 /pmc/articles/PMC8562554/ /pubmed/34729570 http://dx.doi.org/10.1101/2021.10.25.21265493 Text en https://creativecommons.org/publicdomain/zero/1.0/This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license (https://creativecommons.org/publicdomain/zero/1.0/) .
spellingShingle Article
Holmdahl, Inga
Kahn, Rebecca
Slifka, Kara Jacobs
Dooling, Kathleen
Slayton, Rachel B.
Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants
title Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants
title_full Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants
title_fullStr Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants
title_full_unstemmed Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants
title_short Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants
title_sort modeling the impact of vaccination strategies for nursing homes in the context of increased sars-cov-2 community transmission and variants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562554/
https://www.ncbi.nlm.nih.gov/pubmed/34729570
http://dx.doi.org/10.1101/2021.10.25.21265493
work_keys_str_mv AT holmdahlinga modelingtheimpactofvaccinationstrategiesfornursinghomesinthecontextofincreasedsarscov2communitytransmissionandvariants
AT kahnrebecca modelingtheimpactofvaccinationstrategiesfornursinghomesinthecontextofincreasedsarscov2communitytransmissionandvariants
AT slifkakarajacobs modelingtheimpactofvaccinationstrategiesfornursinghomesinthecontextofincreasedsarscov2communitytransmissionandvariants
AT doolingkathleen modelingtheimpactofvaccinationstrategiesfornursinghomesinthecontextofincreasedsarscov2communitytransmissionandvariants
AT slaytonrachelb modelingtheimpactofvaccinationstrategiesfornursinghomesinthecontextofincreasedsarscov2communitytransmissionandvariants

Ejemplares similares