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Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants
Nursing homes (NH) were among the first settings to receive COVID-19 vaccines in the United States, but staff vaccination coverage remains low at an average of 64%. Using an agent-based model, we examined the impact of community prevalence, the Delta variant, staff vaccination coverage, and boosters...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562554/ https://www.ncbi.nlm.nih.gov/pubmed/34729570 http://dx.doi.org/10.1101/2021.10.25.21265493 |
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author | Holmdahl, Inga Kahn, Rebecca Slifka, Kara Jacobs Dooling, Kathleen Slayton, Rachel B. |
author_facet | Holmdahl, Inga Kahn, Rebecca Slifka, Kara Jacobs Dooling, Kathleen Slayton, Rachel B. |
author_sort | Holmdahl, Inga |
collection | PubMed |
description | Nursing homes (NH) were among the first settings to receive COVID-19 vaccines in the United States, but staff vaccination coverage remains low at an average of 64%. Using an agent-based model, we examined the impact of community prevalence, the Delta variant, staff vaccination coverage, and boosters for residents on outbreak dynamics in nursing homes. We found that increased staff primary series coverage and high booster vaccine effectiveness (VE) in residents leads to fewer infections and that the cumulative incidence is highly dependent on community transmission. Despite high VE, high community transmission resulted in continued symptomatic infections in NHs. |
format | Online Article Text |
id | pubmed-8562554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-85625542021-11-03 Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants Holmdahl, Inga Kahn, Rebecca Slifka, Kara Jacobs Dooling, Kathleen Slayton, Rachel B. medRxiv Article Nursing homes (NH) were among the first settings to receive COVID-19 vaccines in the United States, but staff vaccination coverage remains low at an average of 64%. Using an agent-based model, we examined the impact of community prevalence, the Delta variant, staff vaccination coverage, and boosters for residents on outbreak dynamics in nursing homes. We found that increased staff primary series coverage and high booster vaccine effectiveness (VE) in residents leads to fewer infections and that the cumulative incidence is highly dependent on community transmission. Despite high VE, high community transmission resulted in continued symptomatic infections in NHs. Cold Spring Harbor Laboratory 2021-10-26 /pmc/articles/PMC8562554/ /pubmed/34729570 http://dx.doi.org/10.1101/2021.10.25.21265493 Text en https://creativecommons.org/publicdomain/zero/1.0/This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license (https://creativecommons.org/publicdomain/zero/1.0/) . |
spellingShingle | Article Holmdahl, Inga Kahn, Rebecca Slifka, Kara Jacobs Dooling, Kathleen Slayton, Rachel B. Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants |
title | Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants |
title_full | Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants |
title_fullStr | Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants |
title_full_unstemmed | Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants |
title_short | Modeling the impact of vaccination strategies for nursing homes in the context of increased SARS-CoV-2 community transmission and variants |
title_sort | modeling the impact of vaccination strategies for nursing homes in the context of increased sars-cov-2 community transmission and variants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562554/ https://www.ncbi.nlm.nih.gov/pubmed/34729570 http://dx.doi.org/10.1101/2021.10.25.21265493 |
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