Hereditary Xerocytosis: Differential Behavior of PIEZO1 Mutations in the N-Terminal Extracellular Domain Between Red Blood Cells and HEK Cells

Hereditary Xerocytosis, a rare hemolytic anemia, is due to gain of function mutations in PIEZO1, a non-selective cation channel activated by mechanical stress. How these PIEZO1 mutations impair channel function and alter red blood cell (RBC) physiology, is not completely understood. Here, we report...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Yohei, Allegrini, Benoit, Rapetti-Mauss, Raphaël, Picard, Véronique, Garçon, Loïc, Kohl, Peter, Soriani, Olivier, Peyronnet, Rémi, Guizouarn, Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562563/
https://www.ncbi.nlm.nih.gov/pubmed/34737711
http://dx.doi.org/10.3389/fphys.2021.736585

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