White matter integrity in patients with classic trigeminal neuralgia: a multi-node automated fiber tract quantification study

OBJECTIVE: To study the characteristics of point-by-point destruction of white matter tracts in patients using automated fiber tract quantification (AFQ). METHODS: Thirty-four classic trigeminal neuralgia (CTN) patients and 34 healthy control (HC) subjects underwent 3.0 T diffusion tensor magnetic r...

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Autores principales: Li, Rui, Sun, Hongfang, Hao, Hongjuan, Liu, Yali, Zhang, Yang, Zhang, Tianran, Wang, Guangbin, Ming, Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562620/
https://www.ncbi.nlm.nih.gov/pubmed/34719991
http://dx.doi.org/10.1177/03000605211047071
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author Li, Rui
Sun, Hongfang
Hao, Hongjuan
Liu, Yali
Zhang, Yang
Zhang, Tianran
Wang, Guangbin
Ming, Wang
author_facet Li, Rui
Sun, Hongfang
Hao, Hongjuan
Liu, Yali
Zhang, Yang
Zhang, Tianran
Wang, Guangbin
Ming, Wang
author_sort Li, Rui
collection PubMed
description OBJECTIVE: To study the characteristics of point-by-point destruction of white matter tracts in patients using automated fiber tract quantification (AFQ). METHODS: Thirty-four classic trigeminal neuralgia (CTN) patients and 34 healthy control (HC) subjects underwent 3.0 T diffusion tensor magnetic resonance imaging and T1-weighted imaging. The fractional anisotropy (FA) and mean diffusivity (MD) of 100 nodes of 20 fiber tracts were analyzed by AFQ, and the correlations of the FA and MD with the visual analogue scale (VAS) pain score were assessed. RESULTS: The FA values of the left thalamic radiation (middle segment), left corticospinal tract, callosum forceps minor, and right uncinate fasciculus were significantly lower in CTN patients than in the HC group. The MD of the left thalamic tract (middle segment), left corticospinal tract, right superior longitudinal fasciculus, and left superior longitudinal fasciculus (anterior segment) were significantly higher in the CTN group. Additionally, the VAS pain score in CTN patients was positively correlated with FA and negatively correlated with MD. CONCLUSION: Specific fiber tract nodes were damaged in CTN patients, which was related to the VAS pain score. Multi-node quantitative studies of fiber tract damage are valuable for understanding the white matter tract damage pattern in CTN patients.
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spelling pubmed-85626202021-11-03 White matter integrity in patients with classic trigeminal neuralgia: a multi-node automated fiber tract quantification study Li, Rui Sun, Hongfang Hao, Hongjuan Liu, Yali Zhang, Yang Zhang, Tianran Wang, Guangbin Ming, Wang J Int Med Res Retrospective Clinical Research Report OBJECTIVE: To study the characteristics of point-by-point destruction of white matter tracts in patients using automated fiber tract quantification (AFQ). METHODS: Thirty-four classic trigeminal neuralgia (CTN) patients and 34 healthy control (HC) subjects underwent 3.0 T diffusion tensor magnetic resonance imaging and T1-weighted imaging. The fractional anisotropy (FA) and mean diffusivity (MD) of 100 nodes of 20 fiber tracts were analyzed by AFQ, and the correlations of the FA and MD with the visual analogue scale (VAS) pain score were assessed. RESULTS: The FA values of the left thalamic radiation (middle segment), left corticospinal tract, callosum forceps minor, and right uncinate fasciculus were significantly lower in CTN patients than in the HC group. The MD of the left thalamic tract (middle segment), left corticospinal tract, right superior longitudinal fasciculus, and left superior longitudinal fasciculus (anterior segment) were significantly higher in the CTN group. Additionally, the VAS pain score in CTN patients was positively correlated with FA and negatively correlated with MD. CONCLUSION: Specific fiber tract nodes were damaged in CTN patients, which was related to the VAS pain score. Multi-node quantitative studies of fiber tract damage are valuable for understanding the white matter tract damage pattern in CTN patients. SAGE Publications 2021-10-30 /pmc/articles/PMC8562620/ /pubmed/34719991 http://dx.doi.org/10.1177/03000605211047071 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Li, Rui
Sun, Hongfang
Hao, Hongjuan
Liu, Yali
Zhang, Yang
Zhang, Tianran
Wang, Guangbin
Ming, Wang
White matter integrity in patients with classic trigeminal neuralgia: a multi-node automated fiber tract quantification study
title White matter integrity in patients with classic trigeminal neuralgia: a multi-node automated fiber tract quantification study
title_full White matter integrity in patients with classic trigeminal neuralgia: a multi-node automated fiber tract quantification study
title_fullStr White matter integrity in patients with classic trigeminal neuralgia: a multi-node automated fiber tract quantification study
title_full_unstemmed White matter integrity in patients with classic trigeminal neuralgia: a multi-node automated fiber tract quantification study
title_short White matter integrity in patients with classic trigeminal neuralgia: a multi-node automated fiber tract quantification study
title_sort white matter integrity in patients with classic trigeminal neuralgia: a multi-node automated fiber tract quantification study
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562620/
https://www.ncbi.nlm.nih.gov/pubmed/34719991
http://dx.doi.org/10.1177/03000605211047071
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