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Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion
Concussion is associated with disrupted cerebral blood flow (CBF), although there appears to be substantial inter-individual variability in CBF response. At present, the mechanisms of variable CBF response remain incompletely understood, but one potential contributor is matrix metalloproteinase (MMP...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562781/ https://www.ncbi.nlm.nih.gov/pubmed/34727098 http://dx.doi.org/10.1371/journal.pone.0253134 |
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author | Churchill, Nathan W. Di Battista, Alex P. Rhind, Shawn G. Richards, Doug Schweizer, Tom A. Hutchison, Michael G. |
author_facet | Churchill, Nathan W. Di Battista, Alex P. Rhind, Shawn G. Richards, Doug Schweizer, Tom A. Hutchison, Michael G. |
author_sort | Churchill, Nathan W. |
collection | PubMed |
description | Concussion is associated with disrupted cerebral blood flow (CBF), although there appears to be substantial inter-individual variability in CBF response. At present, the mechanisms of variable CBF response remain incompletely understood, but one potential contributor is matrix metalloproteinase (MMP) expression. In more severe forms of acquired brain injury, MMP up-regulation contributes to CBF impairments via increased blood-brain barrier permeability. A similar relationship is hypothesized for concussion, where recently concussed individuals with higher MMP levels have lower CBF. To test this hypothesis, 35 concussed athletes were assessed longitudinally at early symptomatic injury (median: 5 days post-injury) and at medical clearance (median: 24 days post-injury), along with 71 athletic controls. For all athletes, plasma MMPs were measured and arterial spin labelling was used to measure CBF. Consistent with our hypothesis, higher concentrations of MMP-2 and MMP-3 were correlated with lower global CBF. The correlations between MMPs and global CBF were also significantly diminished for concussed athletes at medical clearance and for athletic controls. These results indicate an inverse relationship between plasma MMP levels and CBF that is specific to the symptomatic phase of concussion. Analyses of regional CBF further showed that correlations with MMP levels exhibited some spatial specificity, with greatest effects in occipital, parietal and temporal lobes. These findings provide new insights into the mechanisms of post-concussion cerebrovascular dysfunction. |
format | Online Article Text |
id | pubmed-8562781 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-85627812021-11-03 Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion Churchill, Nathan W. Di Battista, Alex P. Rhind, Shawn G. Richards, Doug Schweizer, Tom A. Hutchison, Michael G. PLoS One Research Article Concussion is associated with disrupted cerebral blood flow (CBF), although there appears to be substantial inter-individual variability in CBF response. At present, the mechanisms of variable CBF response remain incompletely understood, but one potential contributor is matrix metalloproteinase (MMP) expression. In more severe forms of acquired brain injury, MMP up-regulation contributes to CBF impairments via increased blood-brain barrier permeability. A similar relationship is hypothesized for concussion, where recently concussed individuals with higher MMP levels have lower CBF. To test this hypothesis, 35 concussed athletes were assessed longitudinally at early symptomatic injury (median: 5 days post-injury) and at medical clearance (median: 24 days post-injury), along with 71 athletic controls. For all athletes, plasma MMPs were measured and arterial spin labelling was used to measure CBF. Consistent with our hypothesis, higher concentrations of MMP-2 and MMP-3 were correlated with lower global CBF. The correlations between MMPs and global CBF were also significantly diminished for concussed athletes at medical clearance and for athletic controls. These results indicate an inverse relationship between plasma MMP levels and CBF that is specific to the symptomatic phase of concussion. Analyses of regional CBF further showed that correlations with MMP levels exhibited some spatial specificity, with greatest effects in occipital, parietal and temporal lobes. These findings provide new insights into the mechanisms of post-concussion cerebrovascular dysfunction. Public Library of Science 2021-11-02 /pmc/articles/PMC8562781/ /pubmed/34727098 http://dx.doi.org/10.1371/journal.pone.0253134 Text en © 2021 Churchill et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Churchill, Nathan W. Di Battista, Alex P. Rhind, Shawn G. Richards, Doug Schweizer, Tom A. Hutchison, Michael G. Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion |
title | Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion |
title_full | Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion |
title_fullStr | Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion |
title_full_unstemmed | Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion |
title_short | Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion |
title_sort | cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562781/ https://www.ncbi.nlm.nih.gov/pubmed/34727098 http://dx.doi.org/10.1371/journal.pone.0253134 |
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