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Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits

The number of variants that have a non-zero effect on a trait (i.e. polygenicity) is a fundamental parameter in the study of the genetic architecture of a complex trait. Although many previous studies have investigated polygenicity at a genome-wide scale, a detailed understanding of how polygenicity...

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Detalles Bibliográficos
Autores principales:	Johnson, Ruth, Burch, Kathryn S., Hou, Kangcheng, Paciuc, Mario, Pasaniuc, Bogdan, Sankararaman, Sriram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562817/ https://www.ncbi.nlm.nih.gov/pubmed/34673766 http://dx.doi.org/10.1371/journal.pcbi.1009483

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