Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer

Immune evasion is a hallmark of cancer, and therapies that restore immune surveillance have proven highly effective in cancers with high tumor mutation burden (TMB) (e.g., those with microsatellite instability (MSI)). Whether low TMB cancers, which are largely refractory to immunotherapy, harbor pot...

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Detalles Bibliográficos
Autores principales: Westcott, Peter M K, Sacks, Nathan J, Schenkel, Jason M, Ely, Zackery A, Smith, Olivia, Hauck, Haley, Jaeger, Alex M, Zhang, Daniel, Backlund, Coralie M, Beytagh, Mary C, Patten, JJ, Elbashir, Ryan, Eng, George, Irvine, Darrell J, Yilmaz, Omer H, Jacks, Tyler
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562866/
https://www.ncbi.nlm.nih.gov/pubmed/34738089
http://dx.doi.org/10.1038/s43018-021-00247-z

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