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Evaluation of subcutaneous immunotherapy with birch pollen extract for pollen-food allergy syndrome
Some patients with pollen-food allergy syndrome (PFAS) develop systemic symptoms along with oral allergy syndrome upon ingesting processed foods as well as raw fruits and vegetables. This study aimed to investigate the efficacy of subcutaneous immunotherapy with birch pollen extract for patients wit...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asia Pacific Association of Allergy, Asthma and Clinical Immunology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563098/ https://www.ncbi.nlm.nih.gov/pubmed/34786369 http://dx.doi.org/10.5415/apallergy.2021.11.e39 |
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author | Hamada, Masaaki Kagawa, Masakazu Tanaka, Ichiro |
author_facet | Hamada, Masaaki Kagawa, Masakazu Tanaka, Ichiro |
author_sort | Hamada, Masaaki |
collection | PubMed |
description | Some patients with pollen-food allergy syndrome (PFAS) develop systemic symptoms along with oral allergy syndrome upon ingesting processed foods as well as raw fruits and vegetables. This study aimed to investigate the efficacy of subcutaneous immunotherapy with birch pollen extract for patients with PFAS associated with soybean allergy. Subcutaneous immunotherapy with birch pollen extract was introduced in 6 patients with PFAS caused by alder/birch pollen and soybean allergy. An oral food challenge for ingestible amount of soy milk was performed before and 1 year after initiating subcutaneous immunotherapy with birch pollen extract. Before the treatment, the median intake of soy milk was 1.5 mL (interquartile range [IQR], 1–2 mL). One year after the treatment initiation, the median intake of soy milk increased significantly to 150 mL (IQR, 20–200 mL). Systemic reactions occurred in 4 of 6 patients in the rapid escalation phase of the treatment. The results thus suggest that subcutaneous immunotherapy with birch pollen extract could be beneficial for patients with PFAS associated with soybean allergy despite concerns regarding systemic reactions. |
format | Online Article Text |
id | pubmed-8563098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-85630982021-11-15 Evaluation of subcutaneous immunotherapy with birch pollen extract for pollen-food allergy syndrome Hamada, Masaaki Kagawa, Masakazu Tanaka, Ichiro Asia Pac Allergy Hypothesis & Experience Some patients with pollen-food allergy syndrome (PFAS) develop systemic symptoms along with oral allergy syndrome upon ingesting processed foods as well as raw fruits and vegetables. This study aimed to investigate the efficacy of subcutaneous immunotherapy with birch pollen extract for patients with PFAS associated with soybean allergy. Subcutaneous immunotherapy with birch pollen extract was introduced in 6 patients with PFAS caused by alder/birch pollen and soybean allergy. An oral food challenge for ingestible amount of soy milk was performed before and 1 year after initiating subcutaneous immunotherapy with birch pollen extract. Before the treatment, the median intake of soy milk was 1.5 mL (interquartile range [IQR], 1–2 mL). One year after the treatment initiation, the median intake of soy milk increased significantly to 150 mL (IQR, 20–200 mL). Systemic reactions occurred in 4 of 6 patients in the rapid escalation phase of the treatment. The results thus suggest that subcutaneous immunotherapy with birch pollen extract could be beneficial for patients with PFAS associated with soybean allergy despite concerns regarding systemic reactions. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2021-10-19 /pmc/articles/PMC8563098/ /pubmed/34786369 http://dx.doi.org/10.5415/apallergy.2021.11.e39 Text en Copyright © 2021. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Hypothesis & Experience Hamada, Masaaki Kagawa, Masakazu Tanaka, Ichiro Evaluation of subcutaneous immunotherapy with birch pollen extract for pollen-food allergy syndrome |
title | Evaluation of subcutaneous immunotherapy with birch pollen extract for pollen-food allergy syndrome |
title_full | Evaluation of subcutaneous immunotherapy with birch pollen extract for pollen-food allergy syndrome |
title_fullStr | Evaluation of subcutaneous immunotherapy with birch pollen extract for pollen-food allergy syndrome |
title_full_unstemmed | Evaluation of subcutaneous immunotherapy with birch pollen extract for pollen-food allergy syndrome |
title_short | Evaluation of subcutaneous immunotherapy with birch pollen extract for pollen-food allergy syndrome |
title_sort | evaluation of subcutaneous immunotherapy with birch pollen extract for pollen-food allergy syndrome |
topic | Hypothesis & Experience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563098/ https://www.ncbi.nlm.nih.gov/pubmed/34786369 http://dx.doi.org/10.5415/apallergy.2021.11.e39 |
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