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Identification of predictors for persistence of immediate-type egg allergy in Chinese children

BACKGROUND: Egg allergy is one of the most common food allergies in childhood with increasing prevalence in Hong Kong. While ample studies were published on its optimal diagnosis, there was limited data on predictors for the natural history of egg allergy in Asian populations. OBJECTIVE: This study...

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Autores principales: Ngai, Noelle Anne, Leung, Agnes Sze Yin, Leung, Jonathan Chi Ho, Chan, Oi Man, Leung, Ting Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563105/
https://www.ncbi.nlm.nih.gov/pubmed/34786371
http://dx.doi.org/10.5415/apallergy.2021.11.e41
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author Ngai, Noelle Anne
Leung, Agnes Sze Yin
Leung, Jonathan Chi Ho
Chan, Oi Man
Leung, Ting Fan
author_facet Ngai, Noelle Anne
Leung, Agnes Sze Yin
Leung, Jonathan Chi Ho
Chan, Oi Man
Leung, Ting Fan
author_sort Ngai, Noelle Anne
collection PubMed
description BACKGROUND: Egg allergy is one of the most common food allergies in childhood with increasing prevalence in Hong Kong. While ample studies were published on its optimal diagnosis, there was limited data on predictors for the natural history of egg allergy in Asian populations. OBJECTIVE: This study aimed to characterize the clinical course and outcome of children with egg allergy and identify its prognostic factors. METHODS: All Chinese children with immediate-type egg allergy being followed since ≥3 years old in allergy clinic of our university-affiliated teaching hospital were reviewed to determine if they outgrew egg allergy at the latest follow-up. The predictive values of clinical and atopic factors for resolution of egg allergy were analyzed on Kaplan-Meier curves, and factors independently associated with persistent egg allergy was analyzed by logistic regression. RESULTS: Seventy-six patients with median (interquartile range) age 8.9 years (6.3–13.0 years) were recruited. They initially presented with egg-allergic reactions at 1.0 years (0.7–1.7 years). Fifty-four children (71%) were able to tolerate egg at a median of 36 months from initial reaction. Patients with concomitant peanut allergy and those with initial reaction at ≥1 year old were more likely to have persistent egg allergy (p = 0.015 and p = 0.027 respectively). Skin prick test wheal ≥6 mm to egg yolk and egg white individually as well as to both egg yolk and egg white were predictors for egg allergy persistence (respective, p < 0.001, p = 0.001, and p = 0.001 by log-rank tests). Logistic regression showed that initial SPT ≥ 6 mm to egg yolk was the only independent predictor for persistent egg allergy (B = 2.59 ± 0.98, p = 0.008). CONCLUSION: Most Chinese children with immediate-type egg allergy can tolerate egg in long run. SPT wheal size to egg, concomitant peanut allergy and initial presentation after infancy may predict egg allergy persistence.
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spelling pubmed-85631052021-11-15 Identification of predictors for persistence of immediate-type egg allergy in Chinese children Ngai, Noelle Anne Leung, Agnes Sze Yin Leung, Jonathan Chi Ho Chan, Oi Man Leung, Ting Fan Asia Pac Allergy Original Article BACKGROUND: Egg allergy is one of the most common food allergies in childhood with increasing prevalence in Hong Kong. While ample studies were published on its optimal diagnosis, there was limited data on predictors for the natural history of egg allergy in Asian populations. OBJECTIVE: This study aimed to characterize the clinical course and outcome of children with egg allergy and identify its prognostic factors. METHODS: All Chinese children with immediate-type egg allergy being followed since ≥3 years old in allergy clinic of our university-affiliated teaching hospital were reviewed to determine if they outgrew egg allergy at the latest follow-up. The predictive values of clinical and atopic factors for resolution of egg allergy were analyzed on Kaplan-Meier curves, and factors independently associated with persistent egg allergy was analyzed by logistic regression. RESULTS: Seventy-six patients with median (interquartile range) age 8.9 years (6.3–13.0 years) were recruited. They initially presented with egg-allergic reactions at 1.0 years (0.7–1.7 years). Fifty-four children (71%) were able to tolerate egg at a median of 36 months from initial reaction. Patients with concomitant peanut allergy and those with initial reaction at ≥1 year old were more likely to have persistent egg allergy (p = 0.015 and p = 0.027 respectively). Skin prick test wheal ≥6 mm to egg yolk and egg white individually as well as to both egg yolk and egg white were predictors for egg allergy persistence (respective, p < 0.001, p = 0.001, and p = 0.001 by log-rank tests). Logistic regression showed that initial SPT ≥ 6 mm to egg yolk was the only independent predictor for persistent egg allergy (B = 2.59 ± 0.98, p = 0.008). CONCLUSION: Most Chinese children with immediate-type egg allergy can tolerate egg in long run. SPT wheal size to egg, concomitant peanut allergy and initial presentation after infancy may predict egg allergy persistence. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2021-10-25 /pmc/articles/PMC8563105/ /pubmed/34786371 http://dx.doi.org/10.5415/apallergy.2021.11.e41 Text en Copyright © 2021. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ngai, Noelle Anne
Leung, Agnes Sze Yin
Leung, Jonathan Chi Ho
Chan, Oi Man
Leung, Ting Fan
Identification of predictors for persistence of immediate-type egg allergy in Chinese children
title Identification of predictors for persistence of immediate-type egg allergy in Chinese children
title_full Identification of predictors for persistence of immediate-type egg allergy in Chinese children
title_fullStr Identification of predictors for persistence of immediate-type egg allergy in Chinese children
title_full_unstemmed Identification of predictors for persistence of immediate-type egg allergy in Chinese children
title_short Identification of predictors for persistence of immediate-type egg allergy in Chinese children
title_sort identification of predictors for persistence of immediate-type egg allergy in chinese children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563105/
https://www.ncbi.nlm.nih.gov/pubmed/34786371
http://dx.doi.org/10.5415/apallergy.2021.11.e41
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