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Gating pore currents occur in Ca(V)1.1 domain III mutants associated with HypoPP
Mutations in the voltage sensor domain (VSD) of Ca(V)1.1, the α(1S) subunit of the L-type calcium channel in skeletal muscle, are an established cause of hypokalemic periodic paralysis (HypoPP). Of the 10 reported mutations, 9 are missense substitutions of outer arginine residues (R1 or R2) in the S...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563280/ https://www.ncbi.nlm.nih.gov/pubmed/34463712 http://dx.doi.org/10.1085/jgp.202112946 |