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Gating pore currents occur in Ca(V)1.1 domain III mutants associated with HypoPP

Mutations in the voltage sensor domain (VSD) of Ca(V)1.1, the α(1S) subunit of the L-type calcium channel in skeletal muscle, are an established cause of hypokalemic periodic paralysis (HypoPP). Of the 10 reported mutations, 9 are missense substitutions of outer arginine residues (R1 or R2) in the S...

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Detalles Bibliográficos
Autores principales:	Wu, Fenfen, Quinonez, Marbella, Cannon, Stephen C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563280/ https://www.ncbi.nlm.nih.gov/pubmed/34463712 http://dx.doi.org/10.1085/jgp.202112946

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